Results 61 to 70 of about 1,333,689 (304)

In Search of an Audience: Popular Pharmacies and the Limits of Literate Medicine in Late Seventeenth- and Early Eighteenth-Century Russia. [PDF]

open access: yes, 2015
This article addresses the question of the limits of literate medicine in Europe, through an examination of the Russian literate medical world of the late seventeenth and early eighteenth centuries.
Griffin, Clare
core   +4 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Exploring the influence of COVID-19 on studies of frailty and diabetes: A concise review

open access: yesArchives of Gerontology and Geriatrics Plus
This manuscript provides an in-depth exploration of the effects of COVID-19 on frailty and diabetes research, featuring a concise review of relevant literature from the National Library of Medicine.
Yoshiyasu Takefuji, Ph. D.
doaj   +1 more source

Influence network model uncovers relations between biological processes and mutational signatures

open access: yesGenome Medicine, 2023
Background There has been a growing appreciation recently that mutagenic processes can be studied through the lenses of mutational signatures, which represent characteristic mutation patterns attributed to individual mutagens.
Bayarbaatar Amgalan   +3 more
doaj   +1 more source

Pain research in complementary and alternative medicine in Australia: a critical review [PDF]

open access: yes, 2012
Background: Sixty percent (60%) to 80% of patients who visit chiropractic, osteopathic, or Chinese medicine practitioners are seeking pain relief. Objectives: This article aimed to identify the amount, quality, and type of complementary and alternative ...
Xue, C, Zheng, Z
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Ontology-based knowledge representation of experiment metadata in biological data mining [PDF]

open access: yes, 2009
According to the PubMed resource from the U.S. National Library of Medicine, over 750,000 scientific articles have been published in the ~5000 biomedical journals worldwide in the year 2007 alone.
Burke, Squires   +12 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

open access: yesAging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel   +4 more
wiley   +1 more source

Rapid and sensitive detection of genome contamination at scale with FCS-GX

open access: yesGenome Biology
Assembled genome sequences are being generated at an exponential rate. Here we present FCS-GX, part of NCBI’s Foreign Contamination Screen (FCS) tool suite, optimized to identify and remove contaminant sequences in new genomes.
Alexander Astashyn   +18 more
doaj   +1 more source

Pilot implementation of a leadership framework in the National Library of Medicine Associate Fellowship Program [PDF]

open access: yes, 2016
The National Library of Medicine Associate Fellowship Program is a nearly fifty year-old fellowship program for recent library science graduates interested in developing a leadership role in health sciences libraries.
Deardorff, Ariel   +3 more
core  

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