Results 41 to 50 of about 880,844 (243)

Once We Find Grade III Meconium Stained Amniotic Fluid, Must We Act as Early as Possible? [Corrigendum]

International Journal of Women's Health, 2023
Zhu X, Huang S, Tang Y, et al. Int J Womens Health. 2023;15:7–23. The authors have advised that the Funding statement was missed from page 22 of the published paper. The funding statement should read as follows.
Zhu X, Huang S, Tang Y, Wu Z, Sun Y, Ren H, Lu H, Yin T, Zuo Q, Ge Z, Jiang Z   +10 more
doaj  

Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis

EBioMedicine, 2021
Background: Significantly elevated serum and hepatic bile acid (BA) concentrations have been known to occur in patients with liver fibrosis. However, the roles of different BA species in liver fibrogenesis are not fully understood.
Guoxiang Xie, Runqiu Jiang, Xiaoning Wang, Ping Liu, Aihua Zhao, Yiran Wu, Fengjie Huang, Zhipeng Liu, Cynthia Rajani, Xiaojiao Zheng, Jiannan Qiu, Xiaoling Zhang, Suwen Zhao, Hua Bian, Xin Gao, Beicheng Sun, Wei Jia   +16 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Association between the metabolome and bone mineral density in a Chinese population

EBioMedicine, 2020
Background: Osteoporosis is a common metabolic bone disease, which always leads to osteoporotic fractures. Biomarkers of bone mineral density (BMD) are helpful for prevention and early diagnosis of osteoporosis.
Zhendong Mei, Xin Dong, Yu Qian, Dun Hong, Ziang Xie, Guanfeng Yao, An Qin, Songyan Gao, Jianying Hu, Liming Liang, Yan Zheng, Jiacan Su   +11 more
doaj   +1 more source

Patient-specific iPSC-derived cardiomyocytes reveal variable phenotypic severity of Brugada syndromeResearch in context

EBioMedicine, 2023
Summary: Background: Brugada syndrome (BrS) is a cardiac channelopathy that can result in sudden cardiac death (SCD). SCN5A is the most frequent gene linked to BrS, but the genotype–phenotype correlations are not completely matched.
Yaxun Sun, Jun Su, Xiaochen Wang, Jue Wang, Fengfeng Guo, Hangyuan Qiu, Hangping Fan, Dongsheng Cai, Hao Wang, Miao Lin, Wei Wang, Ye Feng, Guosheng Fu, Tingyu Gong, Ping Liang, Chenyang Jiang   +15 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source