Results 41 to 50 of about 35,133 (301)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Planning a multilingual database of higher education terminology
Rasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 2018 The paper aims to study European and Hungarian organisations and institutions that are related to the terminology of education. Then we analyse glossaries, dictionaries and databases that can be found online at the webpages of UNESCO and the European ...
Eszter B. Papp, Ágota Fóris
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Status of official languages of ethnic communities in multiethnic states
, 2020 There are considered three main problems in this article: one of them Is analysis of status differences between official languages in subjects of bi-ethnical and multi-ethnical states.
Farukshin M.
core
, 2022 Com a Carta Europeia das Línguas Regionais ou Minoritárias, o tema das línguas europeias não oficiais, nomeadamente as românicas, parecia ganhar destaque.
Rebelo, Helena
core +1 more source
Southern African Linguistics and Applied Language Studies, 2023 Over the centuries, summative assessment has entrenched itself as a powerful socio-political and educational tool for determining success, or a lack thereof, and is thus critical for shaping a learner’s life. This was particularly prevalent during the apartheid era in South Africa when racially differentiated curricula were crafted.
Moodley, Visvaganthie, Coetse, Adriaan
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Status of official languages of ethnic communities in multiethnic states [PDF]
, 2017 There are considered three main problems in this article: one of them Is analysis of status differences between official languages in subjects of bi-ethnical and multi-ethnical states.
Farukshin M.
core
Official status of languages in the UK and Ireland [PDF]
, 2018 What are the official languages of the United Kingdom and of Ireland? Constitutions typically provide a starting point, although the answer is clearer in the case of the latter than the former.
Daithí Mac Síthigh +1 more
core +1 more source