Results 51 to 60 of about 35,133 (301)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
The development of literacy in indigenous languages in west African francophone countries
Studies in African Languages and CulturesThe French style of governance during colonisation was “assimilation”. It made French the only medium of instruction and communication in schools, thus annihilating African languages and cultures.
Afsat Sanni-Suleiman
doaj +1 more source
The End of Minority Languages? Europe's Regional Languages in Perspective [PDF]
Journal on Ethnopolitics and Minority Issues in Europe, 2012 The European Union (EU) today counts 23 national languages with as many as 65 regional and minority languages, only a few of which enjoy recognition in the EU.
Michael Hornsby, Timofey Agarin
doaj
Bibliothèques captives. Politiques du livre dans les langues de l’État espagnol
La Bretagne Linguistique, 2016 The integration of a ‘cultural’ event with the ideological, spiritual and political positions of individuals and groups within a legally recognised community can, in the case of coexisting languages, provoke such defensive and counter-defensive responses
María Fátima Rodriguez
doaj +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Development and the national language question : a case study
, 2011 Having gone through a colonial history and colonial language policies similar to those of many African countries, Cambodia, the Lao PDR, Myanmar and Vietnam have all chosen a different path when it comes to language policy, opting against retaining a ...
Paulin G. Djité +1 more
core +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source