Results 161 to 170 of about 564,338 (259)

Mackinac National Park and Early National Park Conditions

Journal of the Japanese Institute of Landscape Architects, 1989
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Increasing digital media visibility and tourism messaging promote US National Park system integration. [PDF]

PNAS Nexus
Petersen AM, Arroyave F, Shackelton S, Jenkins JS.   +3 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Ticks and fleas of the critically endangered mountain pygmy-possum (<i>Burramys parvus</i>) in Kosciuszko National Park, Australia. [PDF]

Int J Parasitol Parasites Wildl
Oste DJ, Higgins DP, Bates H, Broome L, van Ogtrop FF, Cho M, Barker SC, Šlapeta J.   +7 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Species Identification and Spatial Diversity Patterns of the Giant Panda National Park (GPNP) in Chengdu, Sichuan, China. [PDF]

Ecol Evol
Wang Q, Xu C, Gou Y, Zhang M, He K, Li Q, Shuai J, Yin C, Wang Z, Yang Z, Yang B.   +10 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Diversity and Ecology of Thrips (Thysanoptera, Insecta) Assemblages in Słowiński National Park-A Biosphere Reserve on the Baltic Coast (Northern Poland). [PDF]

Insects
Kucharczyk H, Kucharczyk M, Zawirska I.
europepmc   +1 more source

Bingham Canyon National Park

Landscape Review, 2018
Frederik Gotemans
doaj   +1 more source