Results 151 to 160 of about 564,338 (259)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mitochondrial diversity of Bwindi Impenetrable National Park Mountain Gorillas. [PDF]

Genome Biol
Knox MA, Almeida V, Kalema-Zikusoka G, Rubanga S, Ngabirano A, Hayman DTS.   +5 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

When the local meets the global: models and challenges of primate conservation in the Fazao-Malfakassa National Park, Togo. [PDF]

Zookeys
Liyabin N, Fousseni F, Aniko PA, Mukete B, Bohnett E, Djagoun C, Gabriel SH, Kperkouma W, Batawila K.   +8 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Discovery of a new species of <i>Coendou</i> (Rodentia: Erethizontidae) within the hyper-diverse mammalian community of Sangay National Park in Ecuador. [PDF]

PeerJ
Brito J, Curay J, León-Caldas V, Lojan-Cueva P, Ojala-Barbour R, Pozo-Zamora G, Simba L, Tito P, Vargas R, Vega-Yánez MA, Batallas D.   +10 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

<i>Cyrtomium lacrimipinnum</i> (Dryopteridaceae), a new sexually reproducing fern from Phong Nha-Ke Bang National Park, Vietnam. [PDF]

PhytoKeys
Yoneoka K, Fujiwara T, Dang VS, Pham QT, Souladeth P, Sengthong A, Masuda R, Yamamoto T, Tanaka N, Tagane S.   +9 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Environmental and Anthropogenic Drivers of Mammalian Functional Diversity in Bénoué National Park, Cameroon. [PDF]

Ecol Evol
Majiteu M, Tamungang SA, Riegert J.
europepmc   +1 more source