Results 151 to 160 of about 8,930,271 (352)
Terrain classification maps of Yellowstone National Park [PDF]
A cooperative ERTS-1 investigation involving U. S. Geological Survey, National Park Service, and Environmental Research Institure of Michigan (ERIM) personnel has as its goal the preparation of terrain classification maps for the entire Yellowstone ...
Roller, N. E. G., Thomson, F. J.
core +1 more source
Regional Study on Social Dimensions of MPA Practice in Central America: Cases Studies from Honduras, Nicaragua, Costa Rica and Panamá [PDF]
, 2013 This research focuses on the social dimensions of marine conservation, and makes an assessment of the experiences of coastal and fishing communities with regard to the governance of MPAs in North America (Central America); based on case studies from ...
Daniela Barguil Gallardo +5 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
PLoS ONEQuantitative evaluation of China's national park policy texts is an important window to understand its national park governance logic, top-level design of ecological protection, and future practice.
Jun-Hui Li +3 more
doaj +1 more source
Getting that Sinking Feeling: Analysis and Impacts of Sea Level Rise on Three National Parks along the East Coast, USA [PDF]
, 2017 Due to global climate change, sea level rise (SLR) has become a threat for future generations, but the extent of this danger is unknown. To help understand the possible effects of SLR on the east coast of the United States, we studied three national ...
Deros, Julia K +2 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Throwing Light on Life at The Wayside
, 2016 Over the course of these past ten weeks, I have come a long way since I started my internship at the beginning of June at Minute Man National Historical Park. This is my second Brian C. Pohanka Internship; last summer, I lived and worked at Harpers Ferry
Andrioli, Alexandria J.
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source