Results 131 to 140 of about 19,817,384 (207)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Petition for the Establishment of a National Park and Forest and Game Preserve

, 2015
The Appalachian National Park Association drafted a number of petitions and resolutions favoring the establishment of a national forest reserve and/or a national park in the southern Appalachians.
Appalachian National Park Association;
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Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Map of proposed boundaries of an Appalachian National Park

, 2015
This map proposes boundaries for a national park in western North Carolina as suggested by the Appalachian National Park Association. The association, formed in 1899, adopted these boundaries in December 1899.
Ambler, Chase P., 1865-1932;
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Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Before the ceremony begins: Mr. Cassidy Uluru, Chairman of the Mutitjulu Community Council with (from the left) Mr. Barry Cohen, Minister for Arts, Heritage and Environment, Professor Derek [i.e. Derrick] Ovington, Director of the National Parks and Wildlife Service, Sir Ninian Stephen and Mr. Clyde Holding [picture] /

, 1985
Part of collection: Uluru (Ayers Rock-Mt. Olga) National Park Handover/Leaseback Ceremony, a pictorial record.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic ...
Uluru (Ayers Rock-Mt. Olga) National Park Handover/Leaseback Ceremony, Uluru-Kata Tjuta National Park (N.T.), 1985.
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NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Yellowstone National Park trip planner, 2010.

, 2009
Shipping list no.: 2010-0087-P.Cover title.Safety tips -- Highlights Visitors Centers Museums -- Activities -- Map -- Lodging & services -- Permits & regulations -- Camping & weather.Mode of access ...
United States. National Park Service.
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Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Editorials commenting on the Appalachian National Park movement

, 2015
This undated, typewritten 20-page document lists various favorable comments made about the Appalachian National Park Association by newspapers and individuals from all over the country.
Ambler, Chase P., 1865-1932;
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