Results 121 to 130 of about 68,143 (261)

Enhanced regional connectivity between western North American national parks will increase persistence of mammal species diversity. [PDF]

Sci Rep, 2023
Newmark WD, Halley JM, Beier P, Cushman SA, McNeally PB, Soulé ME.   +5 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Assessing protected area vulnerability to climate change in a case study of South African national parks. [PDF]

Conserv Biol, 2022
Coldrey KM, Turpie JK, Midgley G, Scheiter S, Hannah L, Roehrdanz PR, Foden WB.   +6 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Genetic Analysis and Status of Brown Bear Sub-Populations in Three National Parks of Greece Functioning as Strongholds for the Species' Conservation. [PDF]

Genes (Basel), 2022
Tsalazidou-Founta TM, Stasi EA, Samara M, Mertzanis Y, Papathanassiou M, Bagos PG, Psaroudas S, Spyrou V, Lazarou Y, Tragos A, Tsaknakis Y, Grigoriadou E, Korakis A, Satra M, Billinis C, Arcprom Project.   +15 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Research on the management of the system construction of National parks with China characteristics: Evidence from policy texts. [PDF]

PLoS One
Li JH, Yu HT, Chen WL, Wang Y.
europepmc   +1 more source

Tourism management in national parks: Šumava and Bayerischer Wald (Bavarian Forest) in the Czech-German borderland. [PDF]

J Mt Sci, 2021
Kołodziejczyk K.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Key design elements and mechanisms for nature-based healing in China's National Parks: insights from expert interviews. [PDF]

Front Public Health
He X, Yin T, He Y, Guo C.
europepmc   +1 more source