Results 141 to 150 of about 18,940,833 (282)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Enhanced regional connectivity between western North American national parks will increase persistence of mammal species diversity. [PDF]

Sci Rep, 2023
Newmark WD, Halley JM, Beier P, Cushman SA, McNeally PB, Soulé ME.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Assessing protected area vulnerability to climate change in a case study of South African national parks. [PDF]

Conserv Biol, 2022
Coldrey KM, Turpie JK, Midgley G, Scheiter S, Hannah L, Roehrdanz PR, Foden WB.   +6 more
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Human-Tiger Conflict in and Around Chitwan-Parsa National Parks: Status, Trends, Contributing Factors, Mitigation Strategies, and Community Perceptions. [PDF]

Ecol Evol
Shrestha A, Pradhan NMB, Subedi N, Shrestha B, Shrestha D, Neupane M, Dahal KP.   +6 more
europepmc   +1 more source

Tourism management in national parks: Šumava and Bayerischer Wald (Bavarian Forest) in the Czech-German borderland. [PDF]

J Mt Sci, 2021
Kołodziejczyk K.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Research on the management of the system construction of National parks with China characteristics: Evidence from policy texts. [PDF]

PLoS One
Li JH, Yu HT, Chen WL, Wang Y.
europepmc   +1 more source

A synthesis of health benefits of natural sounds and their distribution in national parks. [PDF]

Proc Natl Acad Sci U S A, 2021
Buxton RT, Pearson AL, Allou C, Fristrup K, Wittemyer G.   +4 more
europepmc   +1 more source