Results 101 to 110 of about 2,700,922 (312)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
School inclusion: effects of the national education plan on municipal plans
, 2021 This article presents an analysis of the possibilities for public policy, at the national level, to develop into effective municipal policies. Discusses the operationalization of goal 4 of the National Education Plan in the Municipal Education Plans in relation to the continuing education of teachers for school inclusion.
Rigo, Neusete Machado +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Vaccine implementation: Alaska 2017 [PDF]
, 2017 Bacterial meningitis is a serious disease that causes permanent dysfunction or death; adolescents and young adults carry the greatest risk. The national Advisory Committee on Immunization Practices (ACIP) has released vaccine recommendations that include
Hulstine, Amanda
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2006 The New Hampshire Estuaries Project (NHEP) is part of the U.S. Environmental Protection Agency’s National Estuary Program which is a joint local/state/federal program established under the Clean Water Act with the goal of protecting and enhancing ...
Hunter, Jennifer
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Risk Management and Healthcare Policy, 2021 Rashid Menhas,1 Jianhui Dai,2 Muhammad Azeem Ashraf,3 Sohail M Noman,4 Sumaira Khurshid,5 Sajid Mahmood,6 Yu Weng,2 Rizwan Ahmad Laar,7 Xuehui Sang,2 Muhammad Kamran,8 Babar Shahzad,9 Waseem Iqbal9 1Research Center of Sports Social Sciences, School of ...
Menhas R +11 more
doaj
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Measuring University Contributions to Regional Economies: A Discussion of Guidelines for Enhancing Credibility [PDF]
In light of tight state fiscal accounts, increased competition among all government service providers for scarce resources, and a poorly performing national economy, public universities are under increasing pressure to demonstrate their worth to regional
Swenson, David A.
core