Results 91 to 100 of about 442,617 (295)

Physical Inactivity, Non-Communicable Diseases and National Fitness Plan of China for Physical Activity

Risk Management and Healthcare Policy, 2021
Rashid Menhas,1 Jianhui Dai,2 Muhammad Azeem Ashraf,3 Sohail M Noman,4 Sumaira Khurshid,5 Sajid Mahmood,6 Yu Weng,2 Rizwan Ahmad Laar,7 Xuehui Sang,2 Muhammad Kamran,8 Babar Shahzad,9 Waseem Iqbal9 1Research Center of Sports Social Sciences, School of ...
Menhas R, Dai J, Ashraf MA, M Noman S, Khurshid S, Mahmood S, Weng Y, Ahmad Laar R, Sang X, Kamran M, Shahzad B, Iqbal W   +11 more
doaj  

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Guided by National Strategic Needs， Striving to Build a First-Class Forensic Medicine Discipline — The Construction Plan for Forensic Medicine at Southern Medical University

Fayixue Zazhi
The 2024 National Education Work Conference pointed out that at the current juncture of the critical period for achieving the goals and tasks of the 14th Five-Year Plan, the implementation of the Education Powerhouse Construction Plan Outline should be ...
QIAO Dong-fang, QIU Ping-ming, WANG Qi, TAI Yun-chun, LI Dong-ri, XU Jing-tao, LUO Qi-zhi, HUANG En-ping, ZHU Bo-feng   +8 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Internationalization of medical education in Iran: A way towards implementation of the plans of development and innovation in medical education

Journal of Advances in Medical Education and Professionalism, 2018
Introduction: Academic institutions are the most important organizations for implementation of internationalization policies and practices for integrating an international, intercultural and global dimension in higher education system.
EHSAN SHAMSI GOOSHKI, ATA POURABBASI, HAMID AKBARI, NIMA REZAEI, ALI ARAB KHERADMAND, ZAHRA KHEIRY, NILOUFAR PEYKARI, FATEREH MOMENI JAVID, FIROUZEH HAJIPOUR, BAGHER LARIJANI   +9 more
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The National Bilingualism Plan (PNB) and the Challenge of Internationalization in Colombia: Background and Perspectives

Latin American Journal of Content and Language Integrated Learning
This article intends to analyze the interdependence between the National Bilingualism Plan of Colombia and the challenge of internationalization of higher education in the country, as public policies that aim to improve the quality of education at ...
María Emilia Aponte Mantilla
doaj   +1 more source