Results 61 to 70 of about 334,738 (212)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
In memory of Vladimir V. Potemkin
Сахарный диабет, 2022 Vladimir Vasilievich Potemkin is one of the leading endocrinologists in our country, the founder and leader of the first course of endocrinology in the USSR (1973–2017), and then the specialized department of the Russian National Research Medical ...
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
STAFF SATISFACTION ESTIMATION SYSTEMS IN RUSSIAN NATIONAL RESEARCH UNIVERSITIES
Образование и наука, 2015 The aim of the investigation is to study practical approaches to the assessment of employee satisfaction in higher education institutions; to identify and determine the maturity level of assessment systems established in the universities.Methods.
Natalia A. Novokreshchenova
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
THE PATH FROM INDUSTRIAL INSTITUTE TO NATIONAL RESEARCH UNIVERSITY
Высшее образование в России, 2017 Interview with the Rector of Kazan National Research Technical University named after A.N. Tupolev – KAI A.Kh. Gilmutdinov.
A. Kh. Gilmutdinov
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
THE OPINION ABOUT THE RATING SYSTEM IN NATIONAL RESEARCH UNIVERSITY
Высшее образование в России, 2016 The article views the general methodology for objective evaluation of scientificand pedagogical activity of teaching personnel in higher education institutions with the status of «national research university».
Evgeniy A. Kharitonov +2 more
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Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source