Results 71 to 80 of about 334,738 (212)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Research Priorities of Hamadan University of Medical Sciences in 2017: Application of Essential National Health Research (ENHR)

مجله اپیدمیولوژی ایران, 2019
Background and Objectives: Prioritizing the list of required research, taking into account the real needs and problems of the health sector, provides a ground for justice; strengthens the link between research, action, and policy; and addresses the needs
Z Cheraghi, H Mahjub, A Ghalehiha, S Bashirian, H Tayybeenia, A Rahmani, B Naghsh Tabrizi, N Shir Mohammadi, A Farhadi, M Asgarinia, M Karami   +10 more
doaj  

Health research priorities in medical thesis at National University of Piura, 2010-2014 [PDF]

Horizonte Médico, 2016
OBJETIVES To determine the frequency of thesis to obtain the medical degree at the NationalUniversity of Piura (UNP) whose aim was framed within the Peru's nationaland/or Piura's regionalHRP from 201Oto 2014.
Nelson Purizaca-Rosillo, EmanuelRamos-Cedano, NeidyMelendres-Huamán   +2 more
doaj  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

NATIONAL RESEARCH NUCLEAR UNIVERSITY MEPHI: TRANSFORMATIONS FOR LONG-TERM SUSTAINABLE DEVELOPMENT

Высшее образование в России, 2017
In November 2017 the National Research Nuclear University MEPhI will celebrate its 75 year anniversary. In his interview to the journal, the Rector of MEPhI Prof. M.N.
Editorial article
doaj  

MSU – MSU: A Time-Tested Collaboration

Бахтинский вестник
The article examines the collaboration between departments of two Russian universities: the Faculty of Arts at Lomonosov Moscow State University and Institute of National Culture at National Research Mordovia State University.
Natalya I. Voronina
doaj   +1 more source