Results 121 to 130 of about 3,411,532 (259)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Better resourcing of Te Tiriti-led collaboration can be a National Science Challenge legacy. [PDF]

J R Soc N Z
Letica S, Kaye-Blake W, Dickson A, Percy H, Matehaere L, McKeague S.   +5 more
europepmc   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From the 'Deep South' to adaptation for all Aotearoa: reflecting on ten years of the Deep South National Science Challenge. [PDF]

J R Soc N Z
Wreford A, Morgenstern O, Morrison SL, Noone D, Turner KE, Wiles P.   +5 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Quantifying a different way of doing research in the Our Land and Water National Science Challenge. [PDF]

J R Soc N Z
McDowell RW, Llewellyn R, Kaye-Blake W.
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Examining the efforts of the Biological Heritage National Science Challenge Ngā Koiora Tuku Iho to improve equity and diversity in the research system. [PDF]

J R Soc N Z
Finlay-Smits S, Rayne A, Palmer S, McRae KM, Warburton HJ.   +4 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Building mission-led science communication and engagement capability in Aotearoa New Zealand: lessons from the National Science Challenges. [PDF]

J R Soc N Z
McAleer A, Roberts C, Doehring K, Carew C, Brown T, Heine Z, Kirby C, Lowe M, Lyons K, Richardson R, Stayner C, Stein J, Turner K, Whaanga-Schollum D, Wiles G.   +14 more
europepmc   +1 more source