Results 131 to 140 of about 47,913,155 (276)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
The National Science Foundation
American Journal of Public Health and the Nations Health, 1950 openaire +4 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
National Science Foundation: Discoveries
Everyday, research sponsored by the National Science Foundation (NSF) turns up a new discovery, an interesting facet of a scientific endeavor, and sometimes, just something that might delight and amaze even the casual observer.
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National Science Foundation: Resources for STEM Education
, 2011 The National Science Foundation (NSF) has created this useful set of resources related to science, technology, engineering and mathematics (STEM) for educators and others interested in these fields.
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工程科学与技术Materials science and engineering play a pivotal role in supporting our country’s Four Orientations. Advanced materials and manufacturing is the national strategic and basic industry, is the core field involving national security.
Jieren YANG +7 more
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
National Science Foundation: Education-Research Overview
The National Science Foundation (NSF) works on a number of outreach programs designed to improve the quality of science education. This website provides information and materials on this work by offering visitors classroom resources, reports on recent ...
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Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source