Results 81 to 90 of about 18,955 (269)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Civilian popliteal artery injuries : a ten year audit in an urban trauma centre

, 2011
The aim of this study is to identify factors associated with limb loss in patients with popliteal artery injuries. Retrospective chart review of a prospectively collected data base of all patients with popliteal artery injuries presenting to the Groote ...
Banderker, Mohammed Asif
core  

НОВЫЙ МЕТОД ПРОГНОЗИРОВАНИЯ ВЕРОЯТНОСТИ ВЫЖИВАНИЯ И ОЦЕНКИ НЕОПРЕДЕЛЕННОСТИ ДЛЯ ПАЦИЕНТОВ С ТРАВМАМИ

, 2017
The Trauma and Injury Severity Score (TRISS) is the current “gold” standard of screening patient’s condition for purposes of predicting survival probability. More than 40 years of TRISS practice revealed a number of problems, particularly, 1) unexplained
V. I. Gorbachenko, V. G. Schetinin, В. И. Горбаченко, В. Г. Щетинин, V. F. Kuriakin, В. Ф. Курякин, Л. И. Якайте, L. I. Jakaite   +7 more
core   +2 more sources

Prevalence of brachial plexus injuries in patients with scapular fractures: a national trauma data Bank review [PDF]

, 2014
S capular fractures comprise 3% to 5% of all shoulder girdle fractures, while accounting for <1% of all fractures (1). Fracture of the scapula usually occurs after high-energy trauma; thus, approximately 90% of patients have concomitant injuries (2,3).
Edward Chamata Ba, PhD Daniel Jupiter, MD Raman Mahabir, Mr Edward Chamata, MD Robert A Weber   +4 more
core   +2 more sources

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Trauma and Injury Severity Score (TRISS) coefficients 2009 revision

, 2010
BACKGROUND: Currently used Trauma and Injury Severity Score (TRISS) coefficients, which measure probability of survival (PS), were derived from the Major Trauma Outcome Study (MTOS) in 1995 and are now unlikely to be optimal.
Nathens, Avery, Cameron, Cate M, McClure, Roderick J, Cameron, Cate M., Davey, Tamzyn M., Cameron, Cate, McClure, Roderick J., M. Davey, Tamzyn, L. Neal, Melanie, Neal, Melanie L, J. Schluter, Philip, Neal, Melanie L., Goble, Sandra, Schluter, Philip J., Davey, Tamzyn M, J. McClure, Roderick, Schluter, Philip J   +16 more
core   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Comparing regression-adjusted mortality to standardized mortality ratios for trauma center profiling

Journal of Emergencies, Trauma and Shock, 2012
Background: Trauma center profiling is commonly performed with Standardized Mortality Ratios (SMRs). However, comparison of SMRs across trauma centers with different case mix can induce confounding leading to biased trauma center ranks.
Lynne Moore, James A Hanley, Alexis F Turgeon, André Lavoie   +3 more
doaj   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source