Results 91 to 100 of about 18,955 (269)

National analysis of testicular and scrotal trauma in the USA

, 2018
Areg Grigorian, Joshua K Livingston, Sebastian D Schubl, Bima J Hasjim, Daniel Mayers, Eric Kuncir, Cristobal Barrios, Victor Joe, Jeffry Nahmias Division of Trauma, Burns and Surgical Critical Care, Department of Surgery, University of California ...
Schubl SD, Barrios C, Joe V, Livingston JK, Mayers D, Nahmias J, Grigorian A, Kuncir E, Hasjim BJ   +8 more
core  

Machine learning-based prediction of mortality in pediatric trauma patients

Frontiers in Pediatrics
BackgroundThis study aimed to develop a predictive model for mortality outcomes among pediatric trauma patients using machine learning (ML) algorithms.MethodsWe extracted data on a cohort of pediatric trauma patients (18 years and younger) from the ...
Alex Deleon, Anish Murala, Isabelle Decker, Karthik Rajasekaran, Alvaro Moreira   +4 more
doaj   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source

Association of alcohol use with helmet use in cyclists: analysis of the National Trauma Data Bank

Trauma Surgery & Acute Care Open
Background Helmet use significantly reduces the risk of traumatic brain injury among cyclists; however, the influence of alcohol use on helmet-wearing adherence remains understudied in large national data sets.
Chad T Wilson, Daniel C Brock, Gaibo Yan, Emanuel Narcis Husu   +3 more
doaj   +1 more source

Frostbite in the United States: An Examination of the National Burn Repository and National Trauma Data Bank

Journal of Burn Care & Research, 2017
Frostbite is a form of thermal injury that can have devastating consequences for patients, including digit amputations and sometimes more proximal amputations. To the best of the authors' knowledge, no one has determined national characteristics of frostbite patients, nor the prevalence of these diagnostic and therapeutic modalities.
Rachel M, Nygaard, Frederick W, Endorf
openaire   +2 more sources

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

The Impact of National Orthopaedic Fracture Registries: A Systematic Review

OTA International
. Purpose:. Large-scale registry data efforts are common in orthopaedic surgery; however, there is wide variation between registries and little known about registry impact.
Nicolas Jozefowski, BS, Carlo Eikani, BS, Nithya Lingampalli, MD, Patrick Lawler, BS, Athena Barrett, BS, Aaron Hoyt, MD, Andrew Pickles, BS, Elizabeth Huggins, MALIS, Julie Agel, MA, Rachel Seymour, PhD, Mai Nguyen, MD, Meir Marmor, MD, Ashley E. Levack, MD, MAS, the OTA Classification and Outcomes Committee, Stephen Sims, James Kellam, Jarrod Dumpe, Zachary Working, Kyle Schweser   +18 more
doaj   +1 more source

Variation in the use of MRI for cervical spine clearance: an opportunity to simultaneously improve clinical care and decrease cost

Trauma Surgery & Acute Care Open, 2019
Background For years, controversy has existed about the ideal approach for cervical spine clearance in obtunded, blunt trauma patients. However, recent national guidelines suggest that MRI is not necessary for collar clearance in these patients.
Alia Albaghdadi, Ira L. Leeds, Katherine L. Florecki, Joseph K. Canner, Eric B. Schneider, Joseph V. Sakran, Elliott R. Haut   +6 more
doaj   +1 more source