Results 31 to 40 of about 24,640,238 (308)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

The Anxiety of Discovery

open access: yesRSA Journal, 1994
This essay, which is part of a work in progress on the subject, outlines the various views on Native Americans held by Italian explorers, missionaries, travelers, anthropologists, and writers in the past four centuries.
Fedora Giordano
doaj   +1 more source

Undergraduate Minor in Native American Studies [PDF]

open access: yes, 2018
The Native American Studies (NAS) minor is open to all undergraduate, degree-seeking University of Maine students. To declare a minor, obtain a Change of Program/Plan/Sub-Plan form from The Native American Programs office located at Corbett Hall, room ...
University of Maine, Native American Studies Program
core  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

open access: yesFEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez   +4 more
wiley   +1 more source

Hearing the Call: The Cultural and Spiritual Journey of Rosemary McCombs Maxey

open access: yesSouthern Spaces, 2018
In this documentary video, Craig Womack and Steve Bransford explore the continuance of the Creek language, spoken by tribal people in Oklahoma and Florida, by centering upon the life of the Creek community leader, feminist, and activist, Rosemary McCombs
Craig Womack, Steve Bransford
doaj   +1 more source

The Nevada Movement: A Model of Trans-Indigenous Antinuclear Solidarity

open access: yesJournal of Transnational American Studies, 2020
Corbin Harney, Western Shoshone elder and spiritual leader, rises in prayer. He lights a ceremonial pipe and upon inhaling offers it to Olzhas Suleimenov, Kazakh national poet and leader of the Nevada-Semipalatinsk movement, who smokes it in turn.
George Gregory Rozsa
doaj   +1 more source

Native American Studies Quarterly: Volume 11, Issue 1 [PDF]

open access: yes, 2021
This quarterly newsletter about the Native American Studies Center at the University of South Carolina Lancaster provides information on events and activities surrounding the faculty, staff, students, and ...
University of South Carolina Lancaster   +1 more
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Ethnic Cleansing and the Trail of Tears: Cherokee Pasts, Places, and Identities

open access: yesSouthern Spaces, 2017
James Taylor Carson reviews Gregory D. Smithers's The Cherokee Diaspora: An Indigenous History of Migration, Resettlement, and Identity (New Haven: Yale University Press, 2015).
James Taylor Carson
doaj   +1 more source

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