Results 41 to 50 of about 705,880 (306)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Matter-mineral characteristics of technogene placers – potential sources of precious metals (on the example of the Nizhneselemdzhinsky gold-bearing node of Priamurye, Russia)

Georesursy, 2019
Over tens of years of mining and processing of ores and placers of gold in the world a huge amount of wastes originated in the form of spoil heaps and tailing dumps, in which the content of valuable components allow them to be considered a real ...
I.V. Kuznetsova, P.P. Safronov, N.V. Moiseenko   +2 more
doaj   +1 more source

Enrichment of OntoSenseNet: Adding a Sense-annotated Telugu lexicon

, 2018
The paper describes the enrichment of OntoSenseNet - a verb-centric lexical resource for Indian Languages. This resource contains a newly developed Telugu-Telugu dictionary. It is important because native speakers can better annotate the senses when both
Parupalli, Sreekavitha, Singh, Navjyoti
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Mineralogical features, sequence, and formation conditions of polygenic-polychronous mineralization of the Verkhnetatarskaya gold-bearing area (Yenisei Ridge)

Руды и металлы
Based on results of the field and laboratory studies within the Verkhnetatarskaya gold-bearing area (South Yenisei ore district), four sequentially formed mineral complexes have been distinguished and characterized: 1) gold-quartz (native gold (960 ± 20 ‰
Kryazhev S. G., Dvurechenskaya S. S., Berkovsky E. M., Lizorkin I. M., Starostin I. A.   +4 more
doaj   +1 more source

Morphological characteristics and chemical composition of placer gold from the Kengevey River basin and first data on associated platinum-metal mineralization (Magadan region)

Вестник Камчатской региональной ассоциации "Учебно-научный центр". Серия: Науки о Земле, 2023
The paper presents the results of the study of typomorphic characteristics of placer gold of the tributaries of the Kengeveem River, Magadan region. Placer gold was studied by optical and scanning electron microscopy at the Institute of Volcanology and ...
E.D. Skilskaia, Sh.S. Kudaeva
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Gold mineralisation in the Surselva region, Canton Grisons, Switzerland [PDF]

, 2018
The Tavetsch Zwischenmassif and neighbouring Gotthard Massif in the Surselva region host 18 gold-bearing sulphide occurrences which have been investigated for the present study.
Jaffé, Felice
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source