Results 51 to 60 of about 1,914,211 (292)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Geochronology, pyrite trace elements, and sulfur isotope geochemical characteristics of the Saibagou gold deposit in the eastern part of the northern Qaidam Basin

Frontiers in Earth Science, 2023
Introduction: The Saibagou gold deposit, located in the eastern part of the tectonic belt of the northern Qaidam Basin in western China, has its gold ore bodies strictly controlled by the regional fault system.
Jia Xing, Jianguo Wang, Jianbao Liu, Yanguang Liu, Kai Bian, Jianwei Liu, Lina Cai, Shengyun Wei   +7 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

TYPES OF GOLD PLACERS OF THE AMYL-SISTIGKHEM PLACER REGION, WEST SAYAN [PDF]

Минералогия
Native gold from seven placers of the Amyl-Sistighem ore placer region (the Republic of Tyva, Krasnoyarsk region) is classified on the basis of its structure, morphology and chemical composition, which are studied by optical and electronic microscopy ...
Ch.M. Khertek, A.M. Sazonov
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Impact-bonding with aluminum, silver, and gold microparticles: Toward understanding the role of native oxide layer

Applications of Surface Science, 2019
Bonding during cold spray has been phenomenologically associated with the breakup of the native surface oxide layer to produce intimate metallic contacts. Here, we resolve the instant of bonding for metals both with and without a significant native oxide,
M. Hassani-Gangaraj, D. Veysset, K. Nelson, C. Schuh   +3 more
semanticscholar   +1 more source

Prevalence of Systemic Lupus Erythematosus in Australia, 2010–2022: A Population‐Based Study Using Linked National Administrative Health Data

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a heterogenous inflammatory condition with widely varying global prevalence estimates. The frequency of SLE in the general population of Australia has been reported to be notably lower than contemporary estimates in countries such as the United States or United Kingdom, at 19 to 39 per 100,000 as opposed ...
Lucinda Roper, Rachel Black, Joanna Tieu, Winnie Chen, Matthew Parker, Catherine Hill, Natasha Nassar, Mandana Nikpour   +7 more
wiley   +1 more source

The Poputninskoe gold-sulfide deposit, Yenisei Ridge

Руды и металлы
The Poputninskoe gold-sulfide deposit is the largest one in terms of mineral reserves in the southern Yenisei Ridge. The deposit is controlled by the Mamonsko-Rybinsky fault and confined to the axial part of the Rybinsky horst-anticline, in association ...
Nikolay Nikolaevich Kozlov, Aleksandr Vladimirovich Volkov, Konstantin Yurievich Murashov   +2 more
doaj   +1 more source