Results 41 to 50 of about 1,721,014 (269)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

TYPES OF GOLD PLACERS OF THE AMYL-SISTIGKHEM PLACER REGION, WEST SAYAN [PDF]

Минералогия
Native gold from seven placers of the Amyl-Sistighem ore placer region (the Republic of Tyva, Krasnoyarsk region) is classified on the basis of its structure, morphology and chemical composition, which are studied by optical and electronic microscopy ...
Ch.M. Khertek, A.M. Sazonov
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Native gold of the Priamurskaya Province

Zapiski RMO (Proceedings of the Russian Mineralogical Society), 2019
The paper displays data on typomorphic features of native gold in ore deposits and placers of the Priamurskaya Province (Amur River Region). It was revealed that distribution of the number of placers with a certain gold fineness is the unimodal one with a maximum in the range of 850—925 units.
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

SEQUENTIAL EXTRACTION OF SUBSTANCES WITH KNOWN Au SPECIATION – AN EXPERIMENTAL DATA

Геодинамика и тектонофизика, 2022
A study has been conducted on the features of distriburion of Au among the fractions of a 7-step sequential extraction procedure using model substances that are similar in composition to natural organic matter from the dispersion train of sulfide ...
B. Y. Saryg-ool, I. N. Myagkaya, S. M. Zhmodik, T. V. Teplyakova, E. V. Lazareva   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Mineralogical features, sequence, and formation conditions of polygenic-polychronous mineralization of the Verkhnetatarskaya gold-bearing area (Yenisei Ridge)

Руды и металлы
Based on results of the field and laboratory studies within the Verkhnetatarskaya gold-bearing area (South Yenisei ore district), four sequentially formed mineral complexes have been distinguished and characterized: 1) gold-quartz (native gold (960 ± 20 ‰
Kryazhev S. G., Dvurechenskaya S. S., Berkovsky E. M., Lizorkin I. M., Starostin I. A.   +4 more
doaj   +1 more source

Matter-mineral characteristics of technogene placers – potential sources of precious metals (on the example of the Nizhneselemdzhinsky gold-bearing node of Priamurye, Russia)

Georesursy, 2019
Over tens of years of mining and processing of ores and placers of gold in the world a huge amount of wastes originated in the form of spoil heaps and tailing dumps, in which the content of valuable components allow them to be considered a real ...
I.V. Kuznetsova, P.P. Safronov, N.V. Moiseenko   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source