Results 171 to 180 of about 12,547 (268)

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Acetazolamide Use in the Management of Refractory Acute Decompensated Heart Failure in the ICU. [PDF]

Discoveries (Craiova)
Ayyazuddin M, Mendoza A, Patel V, Khan RS, Shah R.   +4 more
europepmc   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Unique Role of Proximal Tubule Dipeptidyl Peptidase 4 on Blood Pressure, Renal Sodium Handling, and Na⁺/H⁺ Exchanger Isoform 3 Phosphorylation. [PDF]

Acta Physiol (Oxf)
Martins FL, Ribeiro-Silva JC, de Jesus EF, Nistala R, Girardi ACC.   +4 more
europepmc   +1 more source

Severe Lower Limb and Abdominal Edema Associated with Subcutaneous Apomorphine Infusion

Movement Disorders Clinical Practice, EarlyView.
Guillaume Costentin, David Maltête
wiley   +1 more source

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer, Daniel Finke, Sebastian Romann, Norbert Frey, Joerg Heineke, Lorenz H. Lehmann   +5 more
wiley   +1 more source

Acetazolamide per os in Decompensated Chronic Heart Failure: Randomized Multicenter Trial ORION-A. [PDF]

J Clin Med
Sabirov I, Rubanenko O, Villevalde S, Rubanenko A, Veselovskaya N, Ivanenko V, Kosheleva N, Menzorov M, Pochinka I, Protasov K, Khasanov N, Yakushin S, Medvedeva E, Duplyakov D, ORION-A Investigators.   +14 more
europepmc   +1 more source

Cardiac surveillance in immune checkpoint inhibitor therapy: Insights from the Essen Cardio‐oncology Registry

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, offering improvements in survival across various malignancies. However, their toxicities pose a major challenge for cardio‐oncology units. Despite their growing importance, data on effectiveness of such specialized units in mitigating ICI‐associated ...
Elias Haj‐Yehia, Lisa Zimmer, Lena Lampe, Dimitra Vlachopoulou, Matthias Totzeck, Tienush Rassaf, Raluca I. Mincu   +6 more
wiley   +1 more source

Urinary sodium to guide diuretic therapy in acute heart failure: results of a national survey. [PDF]

ESC Heart Fail
Cobo Marcos M, Trullàs JC, Perez-Silvestre J, Miró Ò, Quiroga B, Mirabet S, Romero-González G.   +6 more
europepmc   +1 more source

Correction to ‘Natriuretic peptides and C‐reactive protein in in heart failure and malnutrition: A systematic review and meta‐analysis’

ESC Heart Failure, Volume 12, Issue 2, Page 1524-1524, April 2025.
wiley   +1 more source