Results 221 to 230 of about 33,583 (261)
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Dissociation of the Vascular and Natriuretic Effects of Diuretic Agents
1978Diuretic agents of various types and chemical structures exert a vasodilator effect which can be demonstrated as inhibition of noradrenaline-induced vasoconstriction in the isolated, perfused mesenteric artery preparation of the rat. The potency of diuretic agents in this preparation: (GP 48 674 [6-methyl-5-(2-methylene-butyrylbenzofurane-2-carbonic ...
J. Kraetz, L. Criscione, P. R. Hedwall
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A1 receptor antagonists as diuretic/natriuretic agents
Drugs of the Future, 2002Diuretics effectively relieve clinical symptoms and signs in patients with heart failure; however, diuretic resistance and intolerance and diuretic-induced potassium imbalances diminish the efficacy and safety of conventional diuretics. A 1 receptor antagonists prevent the ability of endogenous adenosine to enhance renal epithelial transport.
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Clinical Science, 1990
1. The kidney taken from a rat rendered nephrotic by exposure to puromycin aminonucleoside retains sodium abnormally when perfused in isolation and has an abnormally low vascular resistance (J. D. Firth et al., Clin. Sci. 1989; 76, 387–95). In this study the relation of oxygen consumption to sodium reabsorption has been examined in the isolated ...
J D, Firth, J G, Ledingham
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1. The kidney taken from a rat rendered nephrotic by exposure to puromycin aminonucleoside retains sodium abnormally when perfused in isolation and has an abnormally low vascular resistance (J. D. Firth et al., Clin. Sci. 1989; 76, 387–95). In this study the relation of oxygen consumption to sodium reabsorption has been examined in the isolated ...
J D, Firth, J G, Ledingham
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First enantioselective total synthesis of the endogenous natriuretic agent LLU-α
Tetrahedron Letters, 1999Abstract The endogenous natriuretic agent LLU-α, 1 , has been synthesized from geraniol 4 in 13 steps and 18% overall yield. The two key steps are a Gassman-Sato process to give the phenol 8 and cyclization of the triol 10 with acid to give the chroman 12 with retention of configuration at the tertiary alcohol center. Final oxidation gave 1
Michael E. Jung, James M. MacDougall
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Natriuretic effect of [7-glycine]oxytocin in the presence of diuretic agents in conscious rats.
The Journal of Pharmacology and Experimental Therapeutics, 1980Substitution of the amino acid glycine for 7-proline in oxytocin produces an analog, [7-glycine]oxygocin, having markedly reduced antidiuretic and vasopressor activities but retaining considerable natriuretic activity. We administered this analog alone and with distally acting diuretic agents to test the hypothesis that oxytocin and its analogs ...
C T, Stier, M, Manning, W H, Sawyer
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Atrial natriuretic factors (ANF) and antidiuretic agents.
Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia, 1989The effects of lysine-vasopressin (VP) and pepsanurin (PU) on the diuretic-saluretic action of ANF were investigated. Anaesthetized female rats under constant intravenous perfusion with isotonic glucose solution (0.6 ml/h/100 g body weight) were used.
H R, Croxatto, R, Rosas
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Clinica Chimica Acta, 1987
A highly specific and sensitive radioimmunoassay (RIA) for alpha-human atrial natriuretic peptide (hANP[1-28]) in plasma was developed. The assay used a [125I]monoiodotyrosyl-hANP[1-28] tracer, prepared with an immobilized glycouril agent (Protag) and purified by high pressure liquid chromatography (HPLC), and a highly specific antiserum raised against
F M, Rosmalen +3 more
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A highly specific and sensitive radioimmunoassay (RIA) for alpha-human atrial natriuretic peptide (hANP[1-28]) in plasma was developed. The assay used a [125I]monoiodotyrosyl-hANP[1-28] tracer, prepared with an immobilized glycouril agent (Protag) and purified by high pressure liquid chromatography (HPLC), and a highly specific antiserum raised against
F M, Rosmalen +3 more
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Methylenebutyryl Phenoxyacetic Acid
JAMA, 1963PHARMACOLOGICAL AGENTS which increase salt and water excretion by the kidney represent one of the most significant therapeutic advances in the past decade. Investigation of the nature of the action of these drugs has helped to clarify the mechanisms involved in renal transport of electrolyte and water and has provided information about the homeostatic ...
P J, CANNON, R P, AMES, J H, LARAGH
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Ticrynafen: a novel uricosuric antihypertensive natriuretic agent.
Archives of internal medicine, 1978Interest in new diuretics with less side effects has led to the synthesis of ticrynafen, an uricosuric diuretic. This agent was compared with hydrochlorothiazide in a crossover design study involving 12 hypertensive men. Both agents significantly decreased mean arterial pressure from 8% to 18% in eight of the 12 patients.
J G, de Carvalho +3 more
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ChemInform, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Michael E. Jung, James M. MacDougall
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Michael E. Jung, James M. MacDougall
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