Results 291 to 300 of about 164,451 (332)

C-Type Natriuretic Peptide Analog as Therapy for Achondroplasia

Endocrine Development, 2015
Fibroblast growth factor receptor 3 (FGFR3) is an important regulator of bone formation. Gain-of-function mutations in the FGFR3 gene result in chondrodysplasias which include achondroplasia (ACH), the most common form of dwarfism, in which skull, appendicular and axial skeletons are affected.
L. Legeai-Mallet
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Brain Natriuretic Peptide and C‐Type Natriuretic Peptide Maintain Porcine Oocyte Meiotic Arrest

Journal of Cellular Physiology, 2014
Recent studies have shown that C‐type natriuretic peptide (CNP) serves as a key control system during mouse oocyte maturation. We used pig models (in vitro and in vivo) to explore the role played by the natriuretic peptide family in porcine oocyte maturation.
Guoliang Xia, Ye Yang, Wei Liu, Wenqiang Zhang, Xiao Wang, Qian Chen, Meijia Zhang, Huarong Wang, Yanhao Zhang   +8 more
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C-type natriuretic peptide in childhood obesity

Peptides, 2021
According to the World Health Organization obesity is the result of an energy imbalance between calories assumed and expended and over the past 30 years its incidence has dramatically increased. Recently, the problem of obesity has drastically increased also in childhood, assuming a social relevance.
Manuela Cabiati, Agnese Sgalippa, Giovanni Federico, Silvia Del Ry   +3 more
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C-Type Natriuretic Peptide

Peptides, 1996
C-type natriuretic peptide is a 22-amino acid peptide that was initially identified in the central nervous system. The distribution of C-type natriuretic peptide, which has structural homology with atrial and brain natriuretic peptides, is wide and includes the endothelium, myocardium, gastrointestinal, and genitourinary tracts.
Barr, Craig S., Rhodes, Peter, Struthers, Allan D.   +2 more
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C-type natriuretic peptide and heart failure

Pharmacological Research, 2006
C-type natriuretic peptide (CNP) is a peptide produced by the vascular endothelium with vasodilative properties. It shares structural and physiological properties with the atrial and brain natriuretic peptides (ANP and BNP), whose central role in the pathophysiology of heart failure (CHF) is firmly established.
Del Ry S, Passino C, Emdin M, Giannessi D   +3 more
openaire   +5 more sources

C‐type natriuretic peptide in prostate cancer

APMIS, 2009
C‐type natriuretic peptide (CNP) is expressed in the male reproductive organs in pigs. To examine whether the human prostate also expresses the CNP gene, we measured CNP and N‐terminal proCNP in prostate cancer tissue extracts and performed immunohistochemical biopsy staining.
Nielsen, Soeren Junge, Iversen, Peter, Rehfeld, Jens F., Jensen, Helle Lone, Goetze, Jens Peter   +4 more
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C-type natriuretic peptide: a selective cardiovascular peptide

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1993
Studies were performed in three groups of anesthetized dogs to compare the structurally related peptides atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Group 1 (n = 5) and group 2 (n = 4) received intravenous infusions of CNP or ANP respectively at doses of 10 ng.kg-1.min-1 and 100 ng.kg-1.min-1.
Denise M. Heublein, Chi-Ming Wei, John C. Burnett, Alfredo L. Clavell, A. J. Stingo   +4 more
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TransCon CNP, a Sustained-Release C-Type Natriuretic Peptide Prodrug, a Potentially Safe and Efficacious New Therapeutic Modality for the Treatment of Comorbidities Associated with Fibroblast Growth Factor Receptor 3–Related Skeletal Dysplasias

Journal of Pharmacology and Experimental Therapeutics, 2019
TransCon CNP is a C-type natriuretic peptide (CNP-38) conjugated via a cleavable linker to a polyethylene glycol carrier molecule, designed to provide sustained systemic CNP levels upon weekly subcutaneous administration.
V. Breinholt, C. E. Rasmussen, P. Mygind, M. Kjelgaard‐Hansen, Frank Faltinger, Ana Bernhard, J. Zettler, U. Hersel   +7 more
semanticscholar   +1 more source

Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure

Circulation, 2018
Background: Peripheral vascular resistance has a major impact on arterial blood pressure levels. Endothelial C-type natriuretic peptide (CNP) participates in the local regulation of vascular tone, but the target cells remain controversial.
K. Špiranec, W. Chen, F. Werner, V. Nikolaev, T. Naruke, F. Koch, A. Werner, Petra Eder-Negrin, Rodrigo Diéguez-Hurtado, R. Adams, H. Baba, H. Schmidt, K. Schuh, B. Skryabin, K. Movahedi, F. Schweda, M. Kuhn   +16 more
semanticscholar   +1 more source

C-Type Natriuretic Peptide and Overgrowth

2009
Natriuretic peptides are a family of structurally related peptides with different distinct biological effects. C-type natriuretic peptide (CNP)-mediated signaling is important for endochondral ossification and intervenes in the control of chondrocyte maturation by regulating the balance between proliferation and terminal differentiation. CNP is encoded
BOCCIARDI, RENATA, RAVAZZOLO, ROBERTO
openaire   +4 more sources