Results 1 to 10 of about 69,478 (110)

C-Type Natriuretic Peptide in Essential Hypertension [PDF]

JACC: Basic to Translational Science, 2023
Summary: Multiple mechanisms are involved in essential hypertension. Antihypertensive drugs mainly target increased activity of the sympathetic nervous system, altered production of vasoactive mediators, vascular inflammation, fibrosis, and increased ...
Tara Perunovic, BM, Jens P. Goetze, MD, DMSc   +1 more
doaj   +2 more sources

Perspectives on C‐Type Natriuretic Peptide in Cardiometabolic Disease [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Although CNP (C‐type natriuretic peptide) was first identified in brain tissue, its systemic expression and release is mainly located to the endothelial lining of the vasculature.
Jens P. Goetze, Hiromu Yanagisawa, Hideyuki Kinoshita, John Burnett, Michael Nyberg, Toshio Nishikimi   +5 more
doaj   +2 more sources

C-Type Natriuretic Peptide Derivatives: Orthopaedic Implications in Achondroplasia [PDF]

Journal of the Pediatric Orthopaedic Society of North America
: The recent development of C-type natriuretic peptide (CNP) analogs to increase growth velocity in achondroplasia is now being used alongside limb lengthening procedures.
Emily Qian, MS, Kevin Chen, MD, Rachel Montoya, MD, MPA, MSc, Sanjeev Sabharwal, MD, MPH   +3 more
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Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart [PDF]

Biology, 2022
C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of
Akihiro Yasoda
doaj   +2 more sources

C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity [PDF]

Frontiers in Molecular Neuroscience, 2022
C-type natriuretic peptide (CNP) is highly expressed in the central nervous system (CNS) and key to neuronal development; however, a broader role for CNP in the CNS remains unclear.
Cristina Perez-Ternero, Patrick N. Pallier, Jordi L. Tremoleda, Alessio Delogu, Cathy Fernandes, Cathy Fernandes, Adina T. Michael-Titus, Adrian J. Hobbs   +7 more
doaj   +2 more sources

Pro-C-Type Natriuretic Peptide in Women With Angina Pectoris and No Obstructive Coronary Artery Disease [PDF]

JACC: Advances
Background: Circulating C-type natriuretic peptides (CNPs) predict adverse outcome in women presenting with ST-elevation myocardial infarction. Objectives: The purpose of this study was to determine the prognostic impact of a high proCNP concentration in
Peter D. Mark, MD, PhD, Jakob Schroder, MD, Andreas K. Jensen, MD, Timothy C.R. Prickett, PhD, Eva Prescott, MD, DMSc, Jens P. Goetze, MD, DMSc   +5 more
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C-type natriuretic peptide (CNP) in the paraventricular nucleus-mediated renal sympatho-inhibition [PDF]

Frontiers in Physiology, 2023
Volume reflex produces sympatho-inhibition that is mediated by the hypothalamic paraventricular nucleus (PVN). However, the mechanisms for the sympatho-inhibitory role of the PVN and the neurochemical factors involved remain to be identified.
Hong Zheng, Tapan A. Patel, Xuefei Liu, Kaushik P. Patel   +3 more
doaj   +2 more sources

C-type natriuretic peptide regulates lipid metabolism through a NPRB-PPAR pathway in the intramuscular and subcutaneous adipocytes in chickens [PDF]

Scientific Reports
Natriuretic peptides (NPs) have an important role in lipid metabolism in skeletal muscle and adipose tissue in animals. C-type natriuretic peptide (CNP) is an important NP, but the molecular mechanisms that underlie its activity are not completely ...
Huayun Huang, Longzhou Liu, Zhong Liang, Qianbao Wang, Chunmiao Li, Zhengyang Huang, Zhenhua Zhao, Wei Han   +7 more
doaj   +2 more sources

Endothelial C-type natriuretic peptide/guanylyl cyclase-B signaling prevents pulmonary arterial hypertension [PDF]

Nature Communications
C-type natriuretic peptide (CNP) is released from endothelial cells and acts as an autocrine/paracrine mediator, regulating systemic blood pressure and vascular remodeling via guanylyl cyclase-B (GC-B) and natriuretic peptide receptor-C.
Hiromu Yanagisawa, Koichiro Kuwahara, Yasuaki Nakagawa, Kenji Moriuchi, Hideyuki Kinoshita, Hideaki Inazumi, Takahiko Kanamori, Toshio Nishikimi, Miku Oya, Kazuhiro Nakao, Yohei Ueda, Daisuke Nakamura, Kimihiro Shimizu, Koji Yoshie, Satona Tanaka, Daisuke Nakajima, Ichiro Sakanoue, Akihiro Yasoda, Kazuwa Nakao, Takeshi Kimura, Koh Ono   +20 more
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C‐type natriuretic peptide promotes human granulosa cell growth and estradiol production: Implications for early follicle development [PDF]

Reproductive Medicine and Biology
Purpose To investigate the effects of C‐type natriuretic peptide (CNP) on human granulosa cell growth and elucidate its regulatory mechanisms. Methods A human non‐luteinizing granulosa cell line (HGrC) developed from small antral follicles was used to ...
Yorino Sato, Kazuhiro Kawamura
doaj   +2 more sources