Results 1 to 10 of about 105,569 (311)

Endothelial C-type natriuretic peptide maintains vascular homeostasis [PDF]

Journal of Clinical Investigation, 2014
PMCID: PMC4151218Wellcome Trust (084449/Z/07/Z and 078496/Z/05 ...
Adrian J. Hobbs, Amie J. Moyes, Amrita Ahluwalia, Anne-Sophie Rebstock, Brown, Carlos F. Sánchez Ferrer, Chen, Clavell, Concepción Peiró, David L. Selwood, Fang Xiao, Fernando Rivilla, Filipa Mota, Igaki, Inmaculada Villar, Krejci, Kristen J. Bubb, Ley, Lipinski, Mark J. Caulfield, Michela I. Simone, Morley, Murthy, Natalie G. Lumsden, Paul J. Gane, Pleumeekers, Potter, Raymond J. MacAllister, Rayomand S. Khambata, Reshma S. Baliga, Roberta J. Worthington, Rose, Snezana Djordjevic, Stingo, Stingo, Suga, Susana Vallejo, Trachte, Zuberi   +38 more
core   +5 more sources

Perspectives on C‐Type Natriuretic Peptide in Cardiometabolic Disease [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Although CNP (C‐type natriuretic peptide) was first identified in brain tissue, its systemic expression and release is mainly located to the endothelial lining of the vasculature.
Jens P. Goetze, Hiromu Yanagisawa, Hideyuki Kinoshita, John Burnett, Michael Nyberg, Toshio Nishikimi   +5 more
doaj   +2 more sources

C-Type Natriuretic Peptide in Essential Hypertension

JACC: Basic to Translational Science, 2023
Summary: Multiple mechanisms are involved in essential hypertension. Antihypertensive drugs mainly target increased activity of the sympathetic nervous system, altered production of vasoactive mediators, vascular inflammation, fibrosis, and increased ...
Tara Perunovic, BM, Jens P. Goetze, MD, DMSc   +1 more
doaj   +2 more sources

Endothelial C-type natriuretic peptide/guanylyl cyclase-B signaling prevents pulmonary arterial hypertension [PDF]

Nature Communications
C-type natriuretic peptide (CNP) is released from endothelial cells and acts as an autocrine/paracrine mediator, regulating systemic blood pressure and vascular remodeling via guanylyl cyclase-B (GC-B) and natriuretic peptide receptor-C.
Hiromu Yanagisawa, Koichiro Kuwahara, Yasuaki Nakagawa, Kenji Moriuchi, Hideyuki Kinoshita, Hideaki Inazumi, Takahiko Kanamori, Toshio Nishikimi, Miku Oya, Kazuhiro Nakao, Yohei Ueda, Daisuke Nakamura, Kimihiro Shimizu, Koji Yoshie, Satona Tanaka, Daisuke Nakajima, Ichiro Sakanoue, Akihiro Yasoda, Kazuwa Nakao, Takeshi Kimura, Koh Ono   +20 more
doaj   +2 more sources

Pathogenetic justification of sacubitril / valsartan use in respiratory-cardial comorbidity

Patologìâ, 2023
Among the comorbid conditions that significantly worsen quality of life and life expectancy are the chronic obstructive pulmonary disease and heart failure.
T. V. Ashcheulova, K. M. Kompaniiets, N. M. Herasymchuk, I. V. Sytina   +3 more
doaj   +1 more source

Natriuretic Peptide-Based Novel Therapeutics: Long Journeys of Drug Developments Optimized for Disease States

Biology, 2022
The field of natriuretic peptides (NPs) as an endocrine hormone has been developing since 1979. There are three peptides in humans: atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), which bind to the guanylyl cyclase-A (GC-A ...
Tomoko Ichiki, Atsushi Jinno, Yoshihisa Tsuji   +2 more
doaj   +1 more source

Molecular Mechanism of Blood Pressure Regulation through the Atrial Natriuretic Peptide

Biology, 2022
Natriuretic peptides, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), have cardioprotective effects and regulate blood pressure in mammals.
Takeshi Tokudome, Kentaro Otani
doaj   +1 more source

Mismeasure of C-Type Natriuretic Peptide [PDF]

Clinical Chemistry, 2008
It has been difficult to establish an endocrine role for C-type natriuretic peptide (CNP). Release of CNP from the heart remains to be convincingly demonstrated (1)(2)(3)(4)(5), and data concerning CNP in cardiac disease have been conflicting, possibly because of specificity problems in measurement of CNP.
Nielsen, S.J., Goetze, J.P., Rehfeld, Jens Frederik   +2 more
openaire   +2 more sources

AC-NP: a novel chimeric peptide with natriuretic and vasorelaxing actions. [PDF]

PLoS ONE, 2011
The aim of this study was to evaluate the cardiovascular and renal activities of a newly designed natriuretic peptide (NP). Here, we engineered a novel 28-amino acid chimeric peptide, termed AC-NP that combined the 17-amino acid ring of C type ...
Bao-Ying Chen, Jian-Kang Chen, Miao-Zhang Zhu, Dong-Liang Zhang, Jie-Shen Sun, Jian-Ming Pei, Hua-Song Feng, Xiao-Xing Zhu, Jian Jin, Jun Yu   +9 more
doaj   +1 more source

Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart

Biology, 2022
C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of
Akihiro Yasoda
doaj   +1 more source