Results 1 to 10 of about 23,430 (264)

CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular System

Biology, 2022
The natriuretic peptide family consists of three biologically active peptides: ANP, BNP, and CNP. CNP is more widely expressed than the other two peptides, with significant levels in the central nervous system, osteochondral system, and vascular system ...
Yasuaki Nakagawa, Toshio Nishikimi, Nishikimi Toshio   +2 more
exaly   +4 more sources

Size-dependent cryoprotective effects of curcumin nanoparticles on DNA integrity and motility in cryopreserved Angora buck sperm [PDF]

Frontiers in Veterinary Science
Curcumin is a potent antioxidant and anti-inflammatory agent derived from the Curcuma longa plant. However, its low water solubility and limited bioavailability restrict its effectiveness in cryopreservation applications.
Ali Erdem Öztürk, Serpil Sarıözkan, Mustafa Bodu, Yunus Emre Atay, Derya Şahin, Oya Korkmaz, Caner Öztürk, Zeliha Kılınç, Muge Mirioglu, Nimet Temur, İbrahim Yasir Teǧiş, Merve Şanlı, Mustafa Numan Bucak, İsmail Öçsoy   +13 more
doaj   +2 more sources

Endothelial C-type natriuretic peptide/guanylyl cyclase-B signaling prevents pulmonary arterial hypertension [PDF]

Nature Communications
C-type natriuretic peptide (CNP) is released from endothelial cells and acts as an autocrine/paracrine mediator, regulating systemic blood pressure and vascular remodeling via guanylyl cyclase-B (GC-B) and natriuretic peptide receptor-C.
Hiromu Yanagisawa, Koichiro Kuwahara, Yasuaki Nakagawa, Kenji Moriuchi, Hideyuki Kinoshita, Hideaki Inazumi, Takahiko Kanamori, Toshio Nishikimi, Miku Oya, Kazuhiro Nakao, Yohei Ueda, Daisuke Nakamura, Kimihiro Shimizu, Koji Yoshie, Satona Tanaka, Daisuke Nakajima, Ichiro Sakanoue, Akihiro Yasoda, Kazuwa Nakao, Takeshi Kimura, Koh Ono   +20 more
doaj   +2 more sources

Topical Delivery of CNP-miR146a via a Pluronic Lecithin Organogel Enhances Diabetic Wound Healing [PDF]

Pharmaceutics
Background: Diabetes mellitus is common and associated with numerous complications including diabetic foot ulcers (DFU), which affect a third of patients and are associated with high morbidity and mortality.
Bailey D. Lyttle, James Bardill, Alyssa E. Vaughn, Anisha Apte, Alyssa San Agustin, Elayaraja Kolanthai, Sudipta Seal, David M. Jackson, Kenneth W. Liechty, Carlos Zgheib   +9 more
doaj   +2 more sources

Vosoritide: a drug providing a promising avenue for the treatment of short stature in children with achondroplasia

Journal of Biochemical and Clinical Genetics, 2022
Not available [JBCGenetics 2022; 5(2.000): 059-060]
Amsal Qureshi, Areesha Moiz Alvi
doaj   +1 more source

Is C-type natriuretic peptide regulated by a feedback loop? A study on systemic and local autoregulatory effect.

PLoS ONE, 2020
C-type natriuretic peptide (CNP) is a pivotal enhancer of endochondral bone growth and is expected to be a therapeutic reagent for impaired skeletal growth.
Yohei Ueda, Keisho Hirota, Ichiro Yamauchi, Takuro Hakata, Takafumi Yamashita, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki   +7 more
doaj   +2 more sources

Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill

Scientific Reports, 2021
Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation.
Maximilian J. Wessel, Chang-hyun Park, Elena Beanato, Estelle A. Cuttaz, Jan E. Timmermann, Robert Schulz, Takuya Morishita, Philipp J. Koch, Friedhelm C. Hummel   +8 more
doaj   +1 more source

Targeting the frontoparietal network using bifocal transcranial alternating current stimulation during a motor sequence learning task in healthy older adults

Brain Stimulation, 2022
Background: Healthy older adults show a decrease in motor performance and motor learning capacity as well as in working memory (WM) performance. WM has been suggested to be involved in motor learning processes, such as sequence learning.
L.R. Draaisma, M.J. Wessel, M. Moyne, T. Morishita, F.C. Hummel   +4 more
doaj   +1 more source

Salmonella chitosan nanoparticle vaccine administration is protective against Salmonella Enteritidis in broiler birds

PLoS ONE, 2021
Salmonella control strategies include vaccines that help reduce the spread of Salmonella in poultry flocks. In this study we evaluated the efficacy of administering a live Salmonella vaccine followed by a killed Salmonella chitosan nanoparticle (CNP ...
Keila Y. Acevedo-Villanueva, Sankar Renu, Revathi Shanmugasundaram, Gabriel O. Akerele, Renukaradhy J. Gourapura, Ramesh K. Selvaraj   +5 more
doaj   +2 more sources

Once-weekly TransCon CNP (navepegritide) in children with achondroplasia (ACcomplisH): a phase 2, multicentre, randomised, double-blind, placebo-controlled, dose-escalation trialResearch in context

EClinicalMedicine, 2023
Summary: Background: TransCon CNP (navepegritide) is an investigational prodrug of C-type natriuretic peptide (CNP) designed to allow for continuous CNP exposure with once-weekly dosing.
Ravi Savarirayan, Daniel G. Hoernschemeyer, Merete Ljungberg, Yuri A. Zarate, Carlos A. Bacino, Michael B. Bober, Janet M. Legare, Wolfgang Högler, Teresa Quattrin, M. Jennifer Abuzzahab, Paul L. Hofman, Klane K. White, Nina S. Ma, Dirk Schnabel, Sérgio B. Sousa, Meng Mao, Alden Smith, Mukta Chakraborty, Adebola Giwa, Bent Winding, Birgitte Volck, Aimee D. Shu, Ciara McDonnell   +22 more
doaj   +1 more source