Results 41 to 50 of about 69,844 (264)

The role of C-type natriuretic peptide in cardiovascular medicine [PDF]

European Heart Journal, 2001
0195-668X/01/120997+11 $35.00/0 conventional drug therapy, in order to reduce plasma aminoterminal BNP levels, resulted in reduced total cardiovascular events when compared to therapy directed by clinical acumen. Much less is known about C-type natriuretic peptide (CNP) which was first isolated from porcine brain in 1990. It is now known that CNP has a
Kalra, P. R., Anker, S. D., Struthers, A. D., Coats, A. J. S.   +3 more
openaire   +3 more sources

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

The significance of natriuretic peptides in the evaluation of water-salt metabolism in chronic kidney disease

Терапевтический архив, 2014
The paper discusses the molecular, biochemical, and physiological properties of natriuretic peptides, including the clinical applications of their synthetic formulations, as well as the renal and extrarenal mechanisms of water-salt metabolism in chronic ...
A A Pulin, T Iu Kustova, V V Fomin, N A Mukhin   +3 more
doaj  

C-type natriuretic peptide (CNP) in the paraventricular nucleus-mediated renal sympatho-inhibition

Frontiers in Physiology, 2023
Volume reflex produces sympatho-inhibition that is mediated by the hypothalamic paraventricular nucleus (PVN). However, the mechanisms for the sympatho-inhibitory role of the PVN and the neurochemical factors involved remain to be identified.
Hong Zheng, Tapan A. Patel, Xuefei Liu, Kaushik P. Patel   +3 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

The Effects of C-type Natriuretic Peptide on Craniofacial Skeletogenesis [PDF]

Journal of Dental Research, 2012
C-type natriuretic peptide (CNP) is a potent stimulator of long bone and vertebral development via endochondral ossification. In the present study, we investigated the effects of CNP on craniofacial skeletogenesis, which consists of both endochondral and membranous ossification.
K, Nakao, Y, Okubo, A, Yasoda, N, Koyama, K, Osawa, Y, Isobe, E, Kondo, T, Fujii, M, Miura, K, Nakao, K, Bessho   +10 more
openaire   +2 more sources

The Impact of a Visualized Steerable Sheath on Radiofrequency Catheter Ablation for First‐Time Atrial Fibrillation Ablation: A Prospective, Randomized, Single‐Blind Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background A 3D electroanatomical mapping (3D‐EAM) visualized steerable sheath was designed to improve catheter placement and reduce radiation exposure during ablation, an established treatment for atrial fibrillation (AF). However, prospective randomized data comparing the procedural and clinical outcomes of visualized and non‐visualized ...
Chun‐Kai Chen, Chih‐Chieh Yu, Min‐Tsun Liao, Hui‐Chun Huang, Yen‐Bin Liu   +4 more
wiley   +1 more source

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, EarlyView.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

Molecular Evolution of Shark C-type Natriuretic Peptides

Zoological science, 1994
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Takano, Masayoshi, Sasayama, Yuichi, Takei, Yoshio   +2 more
openaire   +2 more sources

Measurement of Pro-C-Type Natriuretic Peptide in Plasma [PDF]

Clinical Chemistry, 2005
Accurate measurement of peptides derived from pro-C-type natriuretic peptide (proCNP) in human plasma has been difficult for several reasons. Low plasma concentrations necessitate high assay sensitivity. In addition, sufficient specificity can be difficult because of the close sequence homology of CNP with atrial natriuretic peptide (ANP) and B-type ...
Soren Junge, Nielsen, Jens F, Rehfeld, Frants, Pedersen, Jens, Kastrup, Regitze, Videbaek, Jens Peter, Goetze   +5 more
openaire   +2 more sources