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The natriuretic peptides in hypertension
Current Opinion in CARDIOLOGY, 1995The natriuretic peptide family consists of three members: atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Atrial and brain natriuretic peptides possess similar effects, causing natriuresis, vasodilation, and suppression of the renin-angiotensin-aldosterone system.
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Biology of the Natriuretic Peptides
The American Journal of Cardiology, 2008The biology of the natriuretic peptide (NP) system is complex, yet highly phylogenetically preserved. It regulates salt and water handling, promotes vasodilatation, and exerts favorable effects on the heart in the context of processes such as heart failure.
Abelardo, Martinez-Rumayor +3 more
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Nature Reviews Cardiology, 2020
Investigations into the mixed muscle-secretory phenotype of cardiomyocytes from the atrial appendages of the heart led to the discovery that these cells produce, in a regulated manner, two polypeptide hormones - the natriuretic peptides - referred to as atrial natriuretic factor or atrial natriuretic peptide (ANP) and brain or B-type natriuretic ...
Jens P. Goetze +5 more
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Investigations into the mixed muscle-secretory phenotype of cardiomyocytes from the atrial appendages of the heart led to the discovery that these cells produce, in a regulated manner, two polypeptide hormones - the natriuretic peptides - referred to as atrial natriuretic factor or atrial natriuretic peptide (ANP) and brain or B-type natriuretic ...
Jens P. Goetze +5 more
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The Natriuretic Peptides for Hypertension Treatment
High Blood Pressure & Cardiovascular Prevention, 2021Hypertension is a common pathological condition predisposing to a higher occurrence of cardiovascular diseases and events. Unfortunately, treatment of hypertension is still suboptimal worldwide. More efforts are needed to implement the availability of anti-hypertensive drugs.
Rubattu S., Gallo G.
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Natriuretic peptides and hypertension
Current Opinion in Nephrology and Hypertension, 1996Natriuretic peptides are produced in the brain, heart and vasculature, and cause vasodilation, sodium excretion, and diuresis. Recent advances indicate that they play important roles in blood-pressure homeostasis, both in normal and in pathophysiological conditions.
B A, Prins, E, Biesiada, E R, Levin
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Journal of Cardiothoracic Anesthesia, 1989
This report has reviewed some of the cardiovascular aspects of ANP. The emergence of the heart as an endocrine organ requires that numerous questions be asked with regard to the importance of ANP to anesthesia and surgery. It is clear that the interaction of the hormone with other vasoactive compounds, including anesthetic agents, requires further ...
R W, McIntyre, D A, Schwinn
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This report has reviewed some of the cardiovascular aspects of ANP. The emergence of the heart as an endocrine organ requires that numerous questions be asked with regard to the importance of ANP to anesthesia and surgery. It is clear that the interaction of the hormone with other vasoactive compounds, including anesthetic agents, requires further ...
R W, McIntyre, D A, Schwinn
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Current Opinion in Cardiology, 1986
Publisher Summary The natriuretic peptide system consists of three peptides with similar structures. These peptides cause a wide range of actions in the kidney, the vasculature, the heart, and the central nervous system. Atrial natriuretic peptide (ANP) has subsequently been the subject of extensive investigation.
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Publisher Summary The natriuretic peptide system consists of three peptides with similar structures. These peptides cause a wide range of actions in the kidney, the vasculature, the heart, and the central nervous system. Atrial natriuretic peptide (ANP) has subsequently been the subject of extensive investigation.
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Over the last four decades, cardiac natriuretic peptides have changed our understanding of patients with chronic heart failure. From the discovery of the heart as an endocrine organ with its own hormones and receptors, the biochemistry and physiology of the system have been translated into useful biomarkers and drug targets in cardiovascular disease ...
Theodor W, Shalmi +2 more
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Theodor W, Shalmi +2 more
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Dendroaspis natriuretic peptide binds to the natriuretic peptide clearance receptor
Biochemical and Biophysical Research Communications, 2007Dendroaspis natriuretic peptide (DNP) is a newly-described natriuretic peptide which lowers blood pressure via vasodilation. The natriuretic peptide clearance receptor (NPR-C) removes natriuretic peptides from the circulation, but whether DNP interacts with human NPR-C directly is unknown.
Douglas G, Johns +9 more
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[The cardiac natriuretic peptides].
Minerva medica, 2006Cardiac natriuretic peptides (including ANP, BNP, CNP and urodilatin) constitute a family of peptide hormones and neurotransmitters, sharing similar chemical structure (characterized by a cysteine bridge) and biological function. ANP and BNP are cardiac hormones because they are principally produced and secreted by cardiomyocytes.
S. Vittorini, M. Masini, CLERICO, ALDO
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