Results 11 to 20 of about 105,541 (302)

C-Type Natriuretic Peptide in Essential Hypertension [PDF]

JACC: Basic to Translational Science, 2023
Summary: Multiple mechanisms are involved in essential hypertension. Antihypertensive drugs mainly target increased activity of the sympathetic nervous system, altered production of vasoactive mediators, vascular inflammation, fibrosis, and increased ...
Tara Perunovic, BM, Jens P. Goetze, MD, DMSc   +1 more
doaj   +3 more sources

Perspectives on C‐Type Natriuretic Peptide in Cardiometabolic Disease [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Although CNP (C‐type natriuretic peptide) was first identified in brain tissue, its systemic expression and release is mainly located to the endothelial lining of the vasculature.
Jens P. Goetze, Hiromu Yanagisawa, Hideyuki Kinoshita, John Burnett, Michael Nyberg, Toshio Nishikimi   +5 more
doaj   +2 more sources

Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart [PDF]

Biology, 2022
C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of
Akihiro Yasoda
doaj   +2 more sources

Endothelial C-type natriuretic peptide maintains vascular homeostasis [PDF]

Journal of Clinical Investigation, 2014
PMCID: PMC4151218Wellcome Trust (084449/Z/07/Z and 078496/Z/05 ...
Adrian J. Hobbs, Amie J. Moyes, Amrita Ahluwalia, Anne-Sophie Rebstock, Brown, Carlos F. Sánchez Ferrer, Chen, Clavell, Concepción Peiró, David L. Selwood, Fang Xiao, Fernando Rivilla, Filipa Mota, Igaki, Inmaculada Villar, Krejci, Kristen J. Bubb, Ley, Lipinski, Mark J. Caulfield, Michela I. Simone, Morley, Murthy, Natalie G. Lumsden, Paul J. Gane, Pleumeekers, Potter, Raymond J. MacAllister, Rayomand S. Khambata, Reshma S. Baliga, Roberta J. Worthington, Rose, Snezana Djordjevic, Stingo, Stingo, Suga, Susana Vallejo, Trachte, Zuberi   +38 more
core   +5 more sources

C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity [PDF]

Frontiers in Molecular Neuroscience, 2022
C-type natriuretic peptide (CNP) is highly expressed in the central nervous system (CNS) and key to neuronal development; however, a broader role for CNP in the CNS remains unclear.
Cristina Perez-Ternero, Patrick N. Pallier, Jordi L. Tremoleda, Alessio Delogu, Cathy Fernandes, Cathy Fernandes, Adina T. Michael-Titus, Adrian J. Hobbs   +7 more
doaj   +2 more sources

Pro-C-Type Natriuretic Peptide in Women With Angina Pectoris and No Obstructive Coronary Artery Disease [PDF]

JACC: Advances
Background: Circulating C-type natriuretic peptides (CNPs) predict adverse outcome in women presenting with ST-elevation myocardial infarction. Objectives: The purpose of this study was to determine the prognostic impact of a high proCNP concentration in
Peter D. Mark, MD, PhD, Jakob Schroder, MD, Andreas K. Jensen, MD, Timothy C.R. Prickett, PhD, Eva Prescott, MD, DMSc, Jens P. Goetze, MD, DMSc   +5 more
doaj   +2 more sources

C-type natriuretic peptide (CNP) in the paraventricular nucleus-mediated renal sympatho-inhibition [PDF]

Frontiers in Physiology, 2023
Volume reflex produces sympatho-inhibition that is mediated by the hypothalamic paraventricular nucleus (PVN). However, the mechanisms for the sympatho-inhibitory role of the PVN and the neurochemical factors involved remain to be identified.
Hong Zheng, Tapan A. Patel, Xuefei Liu, Kaushik P. Patel   +3 more
doaj   +2 more sources

C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness [PDF]

JCI Insight, 2020
Heart failure is often accompanied by titin-dependent myocardial stiffness. Phosphorylation of titin by cGMP-dependent protein kinase I (PKGI) increases cardiomyocyte distensibility.
Konstanze Michel, Melissa Herwig, Franziska Werner, Katarina Špiranec Spes, Marco Abeßer, Kai Schuh, Swati Dabral, Andreas Mügge, Hideo A. Baba, Boris V. Skryabin, Nazha Hamdani, Michaela Kuhn   +11 more
doaj   +2 more sources

C-type natriuretic peptide: the heart's guardian angel. [PDF]

Eur Heart J, 2020
Abstract
Sangaralingham SJ, Chen Y, Burnett JC.
europepmc   +3 more sources

C-type natriuretic peptide regulates lipid metabolism through a NPRB-PPAR pathway in the intramuscular and subcutaneous adipocytes in chickens [PDF]

Scientific Reports
Natriuretic peptides (NPs) have an important role in lipid metabolism in skeletal muscle and adipose tissue in animals. C-type natriuretic peptide (CNP) is an important NP, but the molecular mechanisms that underlie its activity are not completely ...
Huayun Huang, Longzhou Liu, Zhong Liang, Qianbao Wang, Chunmiao Li, Zhengyang Huang, Zhenhua Zhao, Wei Han   +7 more
doaj   +2 more sources