Results 21 to 30 of about 105,541 (302)

Endothelial C-type natriuretic peptide/guanylyl cyclase-B signaling prevents pulmonary arterial hypertension [PDF]

Nature Communications
C-type natriuretic peptide (CNP) is released from endothelial cells and acts as an autocrine/paracrine mediator, regulating systemic blood pressure and vascular remodeling via guanylyl cyclase-B (GC-B) and natriuretic peptide receptor-C.
Hiromu Yanagisawa, Koichiro Kuwahara, Yasuaki Nakagawa, Kenji Moriuchi, Hideyuki Kinoshita, Hideaki Inazumi, Takahiko Kanamori, Toshio Nishikimi, Miku Oya, Kazuhiro Nakao, Yohei Ueda, Daisuke Nakamura, Kimihiro Shimizu, Koji Yoshie, Satona Tanaka, Daisuke Nakajima, Ichiro Sakanoue, Akihiro Yasoda, Kazuwa Nakao, Takeshi Kimura, Koh Ono   +20 more
doaj   +2 more sources

C‐type natriuretic peptide promotes human granulosa cell growth and estradiol production: Implications for early follicle development [PDF]

Reproductive Medicine and Biology
Purpose To investigate the effects of C‐type natriuretic peptide (CNP) on human granulosa cell growth and elucidate its regulatory mechanisms. Methods A human non‐luteinizing granulosa cell line (HGrC) developed from small antral follicles was used to ...
Yorino Sato, Kazuhiro Kawamura
doaj   +2 more sources

Pathogenetic justification of sacubitril / valsartan use in respiratory-cardial comorbidity

Patologìâ, 2023
Among the comorbid conditions that significantly worsen quality of life and life expectancy are the chronic obstructive pulmonary disease and heart failure.
T. V. Ashcheulova, K. M. Kompaniiets, N. M. Herasymchuk, I. V. Sytina   +3 more
doaj   +1 more source

Natriuretic Peptide-Based Novel Therapeutics: Long Journeys of Drug Developments Optimized for Disease States

Biology, 2022
The field of natriuretic peptides (NPs) as an endocrine hormone has been developing since 1979. There are three peptides in humans: atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), which bind to the guanylyl cyclase-A (GC-A ...
Tomoko Ichiki, Atsushi Jinno, Yoshihisa Tsuji   +2 more
doaj   +1 more source

Molecular Mechanism of Blood Pressure Regulation through the Atrial Natriuretic Peptide

Biology, 2022
Natriuretic peptides, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), have cardioprotective effects and regulate blood pressure in mammals.
Takeshi Tokudome, Kentaro Otani
doaj   +1 more source

Mismeasure of C-Type Natriuretic Peptide [PDF]

Clinical Chemistry, 2008
It has been difficult to establish an endocrine role for C-type natriuretic peptide (CNP). Release of CNP from the heart remains to be convincingly demonstrated (1)(2)(3)(4)(5), and data concerning CNP in cardiac disease have been conflicting, possibly because of specificity problems in measurement of CNP.
Nielsen, S.J., Goetze, J.P., Rehfeld, Jens Frederik   +2 more
openaire   +2 more sources

AC-NP: a novel chimeric peptide with natriuretic and vasorelaxing actions. [PDF]

PLoS ONE, 2011
The aim of this study was to evaluate the cardiovascular and renal activities of a newly designed natriuretic peptide (NP). Here, we engineered a novel 28-amino acid chimeric peptide, termed AC-NP that combined the 17-amino acid ring of C type ...
Bao-Ying Chen, Jian-Kang Chen, Miao-Zhang Zhu, Dong-Liang Zhang, Jie-Shen Sun, Jian-Ming Pei, Hua-Song Feng, Xiao-Xing Zhu, Jian Jin, Jun Yu   +9 more
doaj   +1 more source

Do N-Terminal Pro-C-Type Natriuretic Peptide Levels Relate to Severity of Preeclampsia?

International Journal of Hypertension, 2020
Aim. To compare the plasma N-terminal pro-C-type natriuretic peptide concentrations of normotensive pregnant women, patients with mild preeclampsia, and patients with severe preeclampsia. Methods.
Dogan Vatansever, Pınar Vatansever, Burak Giray, A. Aktug Ertekin, Serpil Bilsel   +4 more
doaj   +1 more source

Roles of Natriuretic Peptides and the Significance of Neprilysin in Cardiovascular Diseases

Biology, 2022
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) activate the guanylyl cyclase A receptor (GC-A), which synthesizes the second messenger cGMP in a wide variety of tissues and cells.
Hitoshi Nakagawa, Yoshihiko Saito
doaj   +1 more source

C-Type Natriuretic Peptide Regulates the Expression and Secretion of Antibacterial Peptide S100A7 in Goat Mammary Gland Through PKG/JNK/c-Jun Signaling Pathway

Frontiers in Veterinary Science, 2022
During infection, the infected tissue secretes a variety of endogenous peptides to resist further invasion of pathogens. Among these endogenous peptides, the natriuretic peptides and the antimicrobial peptides attracted the most attention.
Mingzhen Fan, Mingzhen Fan, Yuyang Miao, Yuyang Miao, Yutong Yan, Yutong Yan, Kunyuan Zhu, Kunyuan Zhu, Xiaoe Zhao, Xiaoe Zhao, Menghao Pan, Menghao Pan, Baohua Ma, Baohua Ma, Qiang Wei, Qiang Wei   +15 more
doaj   +1 more source