British Journal of Pharmacology, EarlyView.Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar +6 more
wiley +1 more source
Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
New Biomarkers in the Prognostic Assessment of Acute Heart Failure with Reduced Ejection Fraction: Beyond Natriuretic Peptides. [PDF]
Int J Mol SciCortés M +13 more
europepmc +1 more source
Asthma and Multimorbidity Amongst Ethnic Minority Groups in High Income Countries
Clinical &Experimental Allergy, EarlyView.There is a tight intersection between asthma, deprivation, ethnicity, multimorbidity and poor clinical outcomes. An integrated, holistic and culturally tailored approach is needed to improve clinical outcomes amongst ethnic minority groups with asthma and multimorbidity. ABSTRACT Asthma is one of the commonest noncommunicable diseases worldwide.
Mamidipudi Thirumala Krishna +6 more
wiley +1 more source
Disproportional ventilatory response to incremental exercise in individuals with cerebral palsy
Developmental Medicine &Child Neurology, EarlyView.Individuals with cerebral palsy demonstrate a disproportionate ventilatory response during incremental exercise. Compared with typically developing peers, respiratory frequency increases earlier and at comparable exercise intensities, contributing to higher perceived exertion and reduced ventilatory efficiency. At task failure, respiratory frequency is
Linnéa Corell +14 more
wiley +1 more source
The Impact of Natriuretic Peptides on Heart Development, Homeostasis, and Disease. [PDF]
CellsGiovou AE, Gladka MM, Christoffels VM.
europepmc +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims To quantify real‐world diagnosis and treatment of obesity in Sweden, describe cardiometabolic comorbidity burden across obesity classes, and compare long‐term cardiovascular outcomes with the general population. Materials and Methods This population‐based cohort study used the AROS (Analysis of Real‐world data of patients with Obesity in ...
Viveca Ritsinger +6 more
wiley +1 more source
Emerging Role of Natriuretic Peptides in Diabetes Care: A Brief Review of Pertinent Recent Literature. [PDF]
Diagnostics (Basel)Tiwari D, Aw TC.
europepmc +1 more source
Prediabetes, Malignant Ventricular Hypertrophy and Stroke: The SPRINT Trial
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Prediabetes and left ventricular hypertrophy (LVH) are common risk factors in adults with hypertension. Whether their coexistence, particularly in the presence of subclinical myocardial injury or stress (malignant LVH), confers a heightened stroke risk is unknown.
Arnaud D. Kaze +7 more
wiley +1 more source
Osteocrin/musclin and the natriuretic peptides system: A novel focus in metabolism and cardiovascular prevention. [PDF]
Exp PhysiolSarzani R +3 more
europepmc +1 more source