Results 81 to 90 of about 966,197 (400)
Advanced Science, EarlyView.Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan +16 more
wiley +1 more source
Natriuretic peptide receptors on rat thymocytes: Inhibition of proliferation by atrial natriuretic peptide. [PDF]
, 1996 Because the thymus expresses the natriuretic peptides (NP) as well as their respective receptors, an involvement of NP in the physiology of this organ has been suggested.
Schmidt, Karin-Nicole +2 more
core +1 more source
Clinics, 2014 OBJECTIVE : The aim of the present study was to evaluate the effects of ovariectomy on the secretory apparatus of natriuretic peptides in right atrial cardiomyocytes. METHODS: Nine-month-old mice underwent bilateral ovariectomy or sham surgery.
Romeu R. de Souza +3 more
doaj +1 more source
Cell surface protein disulfide isomerase regulates natriuretic peptide generation of cyclic guanosine monophosphate. [PDF]
PLoS ONE, 2014 The family of natriuretic peptides (NPs), including atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), exert important and diverse actions for cardiovascular and renal homeostasis.
Shuchong Pan +7 more
doaj +1 more source
Natriuretic peptides for the detection of paroxysmal atrial fibrillation
Open Heart, 2015 Background and purpose Silent atrial fibrillation (AF) and tachycardia (AT) are considered precursors of ischaemic stroke. Therefore, detection of paroxysmal atrial rhythm disorders is highly relevant, but is clinically challenging.
J. Seegers +13 more
semanticscholar +1 more source
Advanced Science, EarlyView.EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen +9 more
wiley +1 more source
Transcription of brain natriuretic peptide and atrial natriuretic peptide genes in human tissues [PDF]
, 1994 We have compared the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes in various human tissues using a quantitative polymerase chain reaction technique.
Dagnino, L. +3 more
core +3 more sources
Natriuretic peptides in cardiovascular diseases: current use and perspectives.
European Heart Journal, 2014 The natriuretic peptides (NPs) family, including atrial, B-type, and C-type NPs, is a group of hormones possessing relevant haemodynamic and anti-remodelling actions in the cardiovascular (CV) system.
M. Volpe, S. Rubattu, J. Burnett
semanticscholar +1 more source
Biochemical Journal, 2001 Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) exert their physiological actions by binding to natriuretic peptide receptor A (NPRA), a receptor guanylate cyclase (rGC) that synthesizes cGMP in response to both ligands. The family of rGCs is rapidly expanding, and it is plausible that there might be additional, as yet undiscovered,
Oliver Smithies +8 more
openaire +4 more sources
Natriuretic Peptides in Heart Failure [PDF]
Clinical Chemistry, 2014 Heart failure is a major global health problem affecting 23 million people worldwide. As more cardiac patients survive and live longer with this progressive disease, heart failure is a condition for which the prevalence will grow. Based solely on clinical presentation, heart failure can be difficult to diagnose since its presentation is complex, with ...
D.C. Lin +5 more
openaire +4 more sources