Results 1 to 10 of about 792 (145)

Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [PDF]

Reviews in Cardiovascular Medicine, 2023
Background: As a fibrinolytic enzyme from fermented soybean, nattokinase has been shown to be potentially beneficial for cardiovascular health, but current clinical evidences regarding the nattokinase supplementation on cardiovascular risk factors are ...
Xinmin Li, Junzi Long, Qian Gao, Mengyang Pan, Jing Wang, Fangjie Yang, Yasu Zhang   +6 more
doaj   +2 more sources

Statistical optimization of fermentation conditions for enhanced production of Nattokinase from Bacillus subtilis MM26 [PDF]

BMC Biotechnology
Background Nattokinase, a potent fibrinolytic serine protease enzyme has drawn significant industrial attention due to its remarkable thrombolytic activity.
M. Maneesha, C. Subathra Devi
doaj   +2 more sources

Transient expression of full-length and mature nattokinase in Nicotiana benthamiana reveals early necrosis from full-length form and functional activity of the mature enzyme [PDF]

Frontiers in Plant Science
Nattokinase is a potent fibrinolytic enzyme widely used in the treatment of cardiovascular diseases for its ability to directly degrade fibrin and plasmin substrates, effectively dissolving blood clots. In this study, both full-length and mature forms of
Kevin Wang, Hugh Mason, Kylie Hall, Ethan Slone, Kylie Tackett, Nan Wang   +5 more
doaj   +2 more sources

Enhanced nattokinase production by Bacillus subtilis from glycerol and okara: optimization of culture medium via response surface methodology [PDF]

Frontiers in Microbiology
IntroductionNattokinase is an alkaline serine protease with potent thrombolytic activity. Due to its safety profile, low cost, and ease of oral administration, it has gained significant attention for therapeutic applications.
Yaling Duan, WanTing Du, Yang Xu, Gege Guo, Zhaoxing Liu, Ning Hao   +5 more
doaj   +2 more sources

Nuclear factor erythroid 2-related factor 2/heme oxygenase-1 activation by nattokinase reduces pro-inflammatory and matrix-degrading mediators in human gingival fibroblasts [PDF]

Journal of Dental Sciences
Background/purpose: Particulate matter (PM) exposure is associated with inflammation and extracellular matrix degradation in periodontal tissues. Cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and matrix metalloproteinase-1 (MMP-1) are key mediators ...
Ya-Lun Li, Yang-Che Wu, Chien-Fu Tseng, Yung-Li Wang, Sin-Yu Li, Thi Thuy Tien Vo, Yuh-Lien Chen, Yin-Tzer Shih, I-Ta Lee   +8 more
doaj   +2 more sources

Combined Computer-Aided Predictors to Improve the Thermostability of Nattokinase [PDF]

Foods, 2023
Food-derived nattokinase has strong thrombolytic activity and few side effects. In the field of medicine, nattokinase has been developed as an adjuvant drug for the treatment of thrombosis, and nattokinase-rich beverages and health foods have also shown ...
Yuan Li, Liangqi Chen, Xiyu Tang, Wenhui Zhu, Aixia Ma, Changyu Shi, Jinyao Li   +6 more
doaj   +2 more sources

Enhanced thermostability of nattokinase by rational design of disulfide bond [PDF]

Microbial Cell Factories
Nattokinase, the thrombolytically active substance in the health food natto, nevertheless, its lower thermostability restricts its use in food and pharmaceutical applications.
Kongfang Yu, Liangqi Chen, Yaolei Tang, Aixia Ma, Wenhui Zhu, Hong Wang, Xiyu Tang, Yuan Li, Jinyao Li   +8 more
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Nattokinase, a Subtilisin-like Alkaline-Serine Protease, Reduces Mutacin Activity by Inactivating the Competence-Stimulating Peptide in Streptococcus mutans [PDF]

Pathogens
Streptococcus mutans is a major cariogenic organism because of its ability to form biofilms on tooth surfaces. Bacteriocins produced by S. mutans (known as mutacins) are indirect pathogenic factors that play a role in the persistence of this microbe in ...
Manami Kimijima, Naoki Narisawa, Eiji Hori, Kengo Mandokoro, Tatsuro Ito, Yukina Ota, Momoko Sashida, Yasushi Kawai, Fumio Takenaga   +8 more
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Genomic and Transcriptomic Analysis of Mutant Bacillus subtilis with Enhanced Nattokinase Production via ARTP Mutagenesis [PDF]

Foods
Nattokinase (NK), a serine protease with high thrombolytic activity, has significant potential for application in foods intended for special health benefits. However, the NK production in wild-type Bacillus subtilis natto is relatively low. In this study,
Liuyu Guo, Yang Chen, Zhiyong He, Zhaojun Wang, Qiuming Chen, Jie Chen, Fatih Oz, Zhimin Xu, Maomao Zeng   +8 more
doaj   +2 more sources

Virtual screening, activity evaluation, and stability of pancreatic lipase inhibitors in the gastrointestinal degradation of nattokinase [PDF]

Heliyon
Nattokinase is an alkaline serine protease secreted by natto during fermentation. Despite its good thrombolytic effect, it is intolerant to gastrointestinal conditions and is easily digested and degraded into polypeptides, oligopeptides, and amino acids.
Lina Yang, Shufang Cao, Mengxi Xie, Taiyuan Shi   +3 more
doaj   +2 more sources