Results 41 to 50 of about 792 (145)

Evaluation of NaTto Red Yeast Rice on Regulating Blood Lipid (ENTRY) Study: A Multicenter, Double-Placebo, Double-Blinded, Randomized Controlled Trial in Chinese Adults. [PDF]

Chronic Dis Transl Med
Study flow chart of the ENTRY study. ABSTRACT Background Statins are the first line of treatment for dyslipidemia, but their side effects often reduce medication compliance. Natto and red yeast rice are natural ingredients with lipid‐lowering effects.
Chen S, Liu F, Li J, Liang F, Li J, Cao J, Liu D, Huang K, Li H, Lu X, Huang J, Gu D.   +11 more
europepmc   +2 more sources

Understanding the concept of Nattokinase use: a few years after beginning

Biotechnology & Biotechnological Equipment, 2023
A number of scientific papers consider the specific and multifunctional pharmacological characteristics of Nattokinase, including those in the context of neuroprotection, neuroregeneration and neuroplasticity.
Dimitar Maslarov, Desislava Drenska, Jane Maslarova-Gelov, Ivan Gelov   +3 more
doaj   +1 more source

A Molecular Probe with Both Chromogenic and Fluorescent Units for Detecting Serine Proteases

Molecules, 2021
A molecular probe with l-phenylalanine p-nitroanilide and l-lysin 4-methylcoumaryl-7-amide, in which these amino acid derivatives are connected through a succinic-acid spacer, was prepared.
Kirara Ishida, Yushi Nakamura, Tetsuo Ohta, Yohei Oe   +3 more
doaj   +1 more source

Research Progress of Nattokinase in Reducing Blood Lipid. [PDF]

Nutrients
The purpose of this paper is to comprehensively review the research progress of nattokinase in lowering blood lipid, including its source, structure and physicochemical properties, mechanisms of functions, clinical research status, and safety considerations, so as to provide reference for further research on the application of nattokinase in the ...
Wei C, Cai R, Song Y, Liu X, Xu HL.
europepmc   +2 more sources

Nattokinase-Promoted Tissue Plasminogen Activator Release from Human Cells [PDF]

Pathophysiology of Haemostasis and Thrombosis, 2007
When heated to a temperature of 70°C or higher, the strong fibrinolytic activity of nattokinase in a solution was deactivated. Similar results were observed in the case of using Suc-Ala-Ala-Pro-Phe-pNA and H-D-Val-Leu-Lys-pNA, which are synthetic substrates of nattokinase.
Chieko, Yatagai, Masugi, Maruyama, Tomoko, Kawahara, Hiroyuki, Sumi   +3 more
openaire   +2 more sources

Transport of Nattokinase across the Rat Intestinal Tract.

Biological and Pharmaceutical Bulletin, 1995
Intraduodenal administration of nattokinase (NK) at a dose of 80 mg/kg, resulted in the degradation of fibrinogen in plasma suggesting transport of NK across the intestinal tract in normal rats. The action of NK on the cleavage of fibrinogen in the plasma from blood samples drawn at intervals after intraduodenal administration of the enzyme was ...
M, Fujita, K, Hong, Y, Ito, S, Misawa, N, Takeuchi, K, Kariya, S, Nishimuro   +6 more
openaire   +3 more sources

Purification and thrombolytic effects in vivo of recombination Nattokinase on carrageenan-induced tail thrombosis in a rat model

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2018
Nattokinase is a serine protease with fibrinolytic activity and has been proven clinical efficacy and safety for human use by the oral route. In this study, conducted purified recombinant nattokinase from Bacillus subtillis DB104 strain and thrombolytic
Tran Quoc Tuan, Dinh Thi Lan Anh, Le Thi Thuy Ai, Dinh Minh Hiep, Tran Cat Dong   +4 more
doaj   +1 more source

Antibacterial Micro/Nanorobots: Innovations, Challenges, and Future Perspectives in Combatting Infection

Nano Select, Volume 7, Issue 2, February 2026.
Antibacterial micro/nanorobots (MNRs) represent a breakthrough in antibacterial therapy, making precise delivery of drugs to the infection site. This review systematically summarizes the material composition, actuation, and applications of MNRs in combating biofilms and drug‐resistant infections while emphasizing the existing challenges of ...
Yichao Chen, Chenlin Jiang, Chuxie Zhang, Wenqing He, Changshun Hou   +4 more
wiley   +1 more source

Targeting the Dynamics Between TAMs and CAR‐T Cells in Solid Tumor Therapies

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This review highlights the critical role of tumor‐associated macrophages (TAMs) in affecting CAR‐T cell therapy effectiveness in solid tumors. TAMs contribute to immune suppression through cytokine secretion, immune checkpoint activation, and metabolic reprogramming, leading to CAR‐T cell exhaustion and reduced efficacy. The article explores strategies
Xiang Zhang, Hao Zheng, Zi‐Chang Liu, Ling‐Jie Luo, Xiao Dong, Xin‐Gang Cui, Yan‐Wei Wu, Liang Chen   +7 more
wiley   +1 more source

Isolation and Optimal Fermentation Condition of the Bacillus subtilis Subsp. natto Strain WTC016 for Nattokinase Production

Fermentation, 2019
Nattokinase is a serine protease in the subtilisin family which is produced by Bacillus subtilis subsp. natto and exhibits vigorous fibrinolytic activity that has been suggested to be able to prevent and treat thromboembolic diseases.
Shouyong Ju, Zhilin Cao, Christina Wong, Yangyang Liu, Mohamed F. Foda, Zhenyu Zhang, Jinshan Li   +6 more
doaj   +1 more source