Results 51 to 60 of about 792 (145)

Development of a Glycerol-Inducible Expression System for High-Yield Heterologous Protein Production in Bacillus subtilis

Microbiology Spectrum, 2022
The development of efficient, low-cost, and robust expression systems is important for the mass production of proteins and natural products in large amounts using cell factories.
Laichuang Han, Qiaoqing Chen, Jie Luo, Wenjing Cui, Zhemin Zhou   +4 more
doaj   +1 more source

Postbiotics in Functional Foods: Microbial Derivatives Shaping Health, Immunity and Next‐Generation Nutrition

Food Frontiers, Volume 7, Issue 1, January 2026.
Postbiotics are bioactive compounds derived from microbial fermentation, including short‐chain fatty acids, extracellular polysaccharides, and cell wall components. These molecules support health by regulating immune responses, enhancing gut barrier integrity, reducing inflammation, and modulating gut–brain and gut–liver communication.
Alice Njolke Mafe, Javad Sharifi‐Rad, Daniela Calina, Ayobami Joshua Ogunyemi, Abiola O. Tubi   +4 more
wiley   +1 more source

A Compartmentalized Joint‐on‐chip (JoC) Model to Unravel the Contribution of Cartilage and Synovium to Osteoarthritis Pathogenesis

Advanced Science, Volume 12, Issue 42, November 13, 2025.
A compartmentalized joint‐on‐chip (JoC) platform is here developed, modelling the interactions between cartilage and synovium in osteoarthritis (OA). Using independent culture and mechanical/biochemical stimulation, the JoC revealed how inflammation and mechanical damage drive mutual tissue changes.
Cecilia Palma, Shima Salehi, Michela Anna Polidoro, Matteo Moretti, Marco Rasponi, Silvia Lopa, Paola Occhetta   +6 more
wiley   +1 more source

Enhanced production of nattokinase from UV mutated Bacillus sp.

Bangladesh Journal of Pharmacology, 2013
In the recent years, nattokinase is one of the most-often employed among the several thrombolytic agents used clinically, particularly because of its lower cost comparing to other thrombolytic agents. In the present research work, Bacillus sp.
V. Mohanasrinivasan, C. Subathra Devi, Ritusree Biswas, Falguni Paul, Mohor Mitra, E. Selvarajan, V. Suganthi   +6 more
doaj   +1 more source

Targeting gut microbiota and metabolites in cancer radiotherapy

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
Radiotherapy (RT) efficacy and toxicity are influenced by gut microbiota and their metabolites. This review explores how probiotics, prebiotics, and microbial byproducts (e.g., short‐chain fatty acids [SCFAs]) mitigate radiation damage and enhance tumour radiosensitivity.
Shuling Ma, Xinpei Li, Shijie Shang, Zijun Zhai, Meng Wu, Qian Song, Dawei Chen   +6 more
wiley   +1 more source

Co-Production of Nattokinase and Poly (γ-Glutamic Acid) Under Solid-State Fermentation Using Soybean and Rice Husk

Brazilian Archives of Biology and Technology, 2015
The aim of this work was to study the co-production of nattokinase and poly (γ-glutamic acid) by Bacillus subtilis natto with soybean and rice husk under solid-state fermentation (SSF).
Guangjun Nie, Zhubin Zhu, Fang Liu, Zhijie Nie, Yuchao Ye, Wenjin Yue   +5 more
doaj   +1 more source

Study on the enzymatic properties of Nattokinase [PDF]

Advances in Engineering Research, 2015
The fractionation by (NH4)2SO4 of nattokinase was studied,the (NH4)2SO4saturation of 30%was selected to remove impurity protein, (NH4)2SO4 saturation of 60% was seleted to precipitate nattokinase.The nattokinase was purified bysalting out method to obtain the crude enzyme solution,the enzymatic properties of nattokinase were studied.The nattokinase was
openaire   +1 more source

Nattokinase Crude Extract Inhibits Hepatocellular Carcinoma Growth in Mice

Journal of Microbiology and Biotechnology, 2019
Nattokinase (NK, E.C. 3.4.21.62) is a serine protease produced by Bacillus subtilis natto that shows promise for the treatment of thrombotic disease. In this study, we assessed the effects of NK on the development of hepatocellular carcinoma (HCC), a principal malignancy of the liver that causes morbidity and mortality worldwide.
Yongmin, Yan, Yanjing, Wang, Jiali, Qian, Sihui, Wu, Yi, Ji, Yanxiao, Liu, Jian, Zeng, Aihua, Gong   +7 more
openaire   +3 more sources

Safety evaluation of the food enzyme thermomycolin from the genetically modified Trichoderma reesei strain AR‐201

EFSA Journal, Volume 23, Issue 10, October 2025.
Abstract The food enzyme thermomycolin (EC 3.4.21.65) is produced with the genetically modified Trichoderma reesei strain AR‐201 by AB Enzymes GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism and its DNA.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Ana Gomes, Magdalena Andryszkiewicz, Daniele Cavanna, Natália Kovalkovičová, Silvia Peluso, Yi Liu   +18 more
wiley   +1 more source

Insights on the therapeutic potential of fibrinolytic enzymes, emphasis on Nattokinase and its enhanced production using advanced technologies: a critical review

Discover Applied Sciences
Background Nattokinase is pivotal in managing cardiovascular disease (CVD) and it serves as a natural adjunct in treating circulatory conditions, offering reduced risks and enhanced cost-effectiveness.
Anju Kanjirakandi Ashokan, V. Mohanasrinivasan   +1 more
doaj   +1 more source