Results 181 to 190 of about 403 (213)

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

[Anthropogenic transformation of the environment and morbidity of infections with natural focality in the Ul'ianovsk region].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 2003
openaire   +1 more source

Sodium Ascorbate‐Accelerated Gelling Hydrogels With Rapid Self‐Mineralized Capacity for Chronic Wounds

Advanced Science, EarlyView.
An immunoregulatory hydrogel based on sodium ascorbate (SA)‐accelerated gelation and in situ self‐mineralization is prepared here. Such a hydrogel is constructed by mixing benzaldehyde‐ and cyanoacetate‐functionalized dextran with silver nitrate (AgNO3) and SA, enabling the ultrafast solidification and in situ self‐mineralization of silver ...
Xiaoya Ding, Wei Yang, Wenzhao Li, Guifang Xu, Yuanjin Zhao   +4 more
wiley   +1 more source

[Natural focal infections transmitted by Ixodes ticks in the Iaroslavl region: epidemiological aspects].

Meditsinskaia parazitologiia i parazitarnye bolezni, 2004
T A, Druzhinina, V V, Pogodina, N G, Bochkova, G V, Iushchenko, S A, Meliuk, L V, Skorodumova, T P, Barmotina   +6 more
openaire   +1 more source

[Levels and mechanisms of the regulation of the population count of the causative agents of natural focal infections].

Meditsinskaia parazitologiia i parazitarnye bolezni, 1986
openaire   +1 more source

Some of the next articles are maybe not open access.

Related searches:

NATURAL FOCAL INFECTIONS IN DONETSK REGION

Military and tactical medicine. Emergency medicine, 2022
изучить клиническое течение туляремии и везикулезного риккетсиоза на современном этапе в Донбассе research of tularemia and vesicular rickettsiosis current clinical course in ...
exaly   +2 more sources

About method of prediction morbidity natural-focal infections

Journal of New Medical Technologies, 2014
Epidemiological analysis of morbidity natural-focal infections showed, that at Tula state territory registers high level of morbidity leptospirosis, hemolytic fever with renal syndrome, that exceeds morbidity at Central Federal State and average Russian indexes. For prediction of morbidity used analysis of time series, regression analysis, method group
V. Evstegneeva, null Евстегнеева   +1 more
exaly   +2 more sources