A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses [PDF]
, 2013 Annette Kampa +8 more
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Valorization of artichoke outer petals by using ultrasound‐assisted extraction and natural deep eutectic solvents (
, 2023 Gülay Özkan
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HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Isoproterenol Induced Myocardial Infarction: Protective Role of Natural Products [PDF]
, 2010 Aman Upaganlawar +2 more
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Influences of Divalent Ions in Natural Seawater/River Water on Nanofluidic Osmotic Energy Generation [PDF]
, 2022 Fenhong Song +4 more
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Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Understanding hydroclimate processes in the Murray-Darling Basin for natural resources management [PDF]
, 2012 Ailie Gallant +4 more
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Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source