Results 81 to 90 of about 647,940 (263)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Dam-breach process simulation and risk assessment of outburst flood induced by the Tangjiashan landslide-dammed lake

Journal of Hydrology: Regional Studies
Study region: This study focuses on the Tangjiashan landslide-dammed lake (TJSLL), located in Beichuan County, Sichuan Province, China, which experienced a large outburst flood (OF) following the 2008 Wenchuan Earthquake.
Junxue Ma, Chong Xu, Jian Chen
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Identification and distribution of 13003 landslides in the northwest margin of Qinghai-Tibet Plateau based on human-computer interaction remote sensing interpretation

China Geology
: The periphery of the Qinghai-Tibet Plateau is renowned for its susceptibility to landslides. However, the northwestern margin of this region, characterised by limited human activities and challenging transportation, remains insufficiently explored ...
Wei Wang, Yuan-dong Huang, Chong Xu, Xiao-yi Shao, Lei Li, Li-ye Feng, Hui-ran Gao, Yu-long Cui, Shuai Wu, Zhi-qiang Yang, Kai Ma   +10 more
doaj   +1 more source

Anticancer Activity of Natural Compounds [PDF]

Asian Pacific Journal of Cancer Prevention, 2021
Abdul Q, Khan, Shahab, Uddin
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Quantifying spatiotemporal dynamics of soil frost heave over the Qinghai-Tibet Plateau with process-based hydrothermal modeling

Geoderma
The frost heave phenomenon in frozen soil serves as a direct factor that can induce surface ground deformation and heighten the risk of geological hazards. Quantitative research on frozen soil dynamics and its frost heave at the regional scale is pivotal
Huiran Gao, Yaning Yi, Chong Xu, Wanchang Zhang, Zhijie Zhang, Hao Chen, Jinping Liu, Wenwen Qi, Zikang Xiao, Yuandong Huang   +9 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The landslide traces inventory in the transition zone between the Qinghai-Tibet Plateau and the Loess Plateau: a case study of Jianzha County, China

Frontiers in Earth Science
The upper reaches of the Yellow River in China, influenced by erosion of the Yellow River and tectonic activities, are prone to landslides. Therefore, it is necessary to investigate the existing landslide traces.
Tao Li, Tao Li, Chong Xu, Chong Xu, Lei Li, Jixiang Xu   +5 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source