Results 91 to 100 of about 1,376,167 (262)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Spatial–Temporal Patterns of Cultural Heritage in the Three Gorges of the Yangtze River and Their Relationship with the Natural Environment

Heritage
Against the backdrop of a gradual shift in the focus of cultural heritage (CH) conservation and utilization toward the integrated system formed by CH and its surrounding environment as well as regional systems, research on the coordinated protection of ...
Yinghuaxia Wu, Huasong Mao, Yu Cheng
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Freeze–Thaw Resistance of Class C/Class F Fly Ash Geopolymer Mortars with Different Ash-to-Sand Ratios

Buildings
This paper investigates the freeze–thaw durability of geopolymer mortars synthesized from class C and class F fly ash, with varying ash-to-sand ratios ranging from 1:1 to 1:1.8.
Xiaodong Li, Zhenyu Chu, Ge Zhu, Tao Yu, Hengqiang Su, Yueyong Shao, Xueying Li, Zhenpeng Jiang, Zhenzhen Jiao   +8 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Designing for Comfort in VR Public Speaking: How Avatar Realism and Natural Environments Shape User Experience and Stress Responses

Behavioral Sciences
Virtual reality (VR) is increasingly used in public speaking training, yet the distinct roles of environmental context and virtual audience design remain unclear. This study examines how avatar visual style (realistic vs.
Han Zhang, Rui Peng, Shiyi Wang, Hanting Song, Zijian Li   +4 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

HALLAZGO DE OOFAGIA CANIBALÍSTICA EN PELTOCEPHALUS DUMERILIANUS: (TESTUDINES: PODOCNEMIDIDAE) DISCOVERY OF CANNIBALISTIC OOPHAGY IN PELTOCEPHALUS DUMERILIANUS: (TESTUDINES: PODOCNEMIDIDAE)

Actualidades Biológicas, 2009
Se presenta por primera vez el hallazgo de oofagia canibalística en Peltocephalus dumerilianus (Schweigger, 1812) (Testudines: Podocnemididae), detectada durante un estudio de dieta en medio natural para esta especie, en el cual se examinaron muestras de
Jaime De La Ossa V., Richard C. Vogt, Alejandro De La Ossa Lacayo   +2 more
doaj  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source