Results 61 to 70 of about 5,709,277 (284)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

GATE -- an Environment to Support Research and Development in Natural Language Engineering [PDF]

, 1996
We describe a software environment to support research and development in natural language (NL) engineering. This environment -- GATE (General Architecture for Text Engineering) -- aims to advance research in the area of machine processing of natural ...
Cunningham, Hamish, Gaizauskas, Robert, Humphreys, Kevin, Rodgers, Peter, Wilks, Yorick   +4 more
core   +4 more sources

Organic matter remineralization in marine sediments : A Pan-Arctic synthesis [PDF]

, 2017
Natural Environment Research Council (GrantNumber(s): NE/J023094/1; Grant recipient(s): Ursula Witte) ArcticNet (GrantNumber(s): Hotspot biodiversity project; Grant recipient(s): Philippe Archambault)Peer reviewedPublisher ...
Aller, Ambrose, Ambrose, Andersson, Ardyna, Ardyna, Ardyna, Arnosti, Arrigo, Arrigo, Arrigo, Baldwin, Berg, Bergeron, Bianchi, Bidle, Boetius, Boetius, Buesseler, Bélanger, Campbell, Carmack, Carmack, Carroll, Chen, Christensen, Clough, Clough, Darnis, Davenport, Devol, Dittmar, Doxaran, Dunton, Déry, Engelsen, Findlay, Fujiwara, Gaillard, Gaye, Glud, Glud, Glud, Goñi, Goñi, Grant, Grebmeier, Grebmeier, Grebmeier, Grebmeier, Grebmeier, Grebmeier, Grebmeier, Guo, Haine, Harada, Hartnett, Hastie, Hensen, Hill, Hill, Hodal, Hoegh-Guldberg, Hulth, Hulth, Hunt, Jahnke, Jakobsson, Ji, Juul-Pedersen, Jørgensen, Kahru, Kenchington, Kirchman, Kirchman, Klein, Lalande, Le Fouest, Lein, Leu, Li, Link, Link, Link, Lohrer, Lowry, Maslowski, Mathis, McClelland, McKee, McMahon, Michaud, Michaud, Michel, Michel, Michel, Middelburg, Moran, Morata, Morata, Morata, Morison, Na, Nedwell, Olli, Orlova, Pabi, Petrenko, Pfannkuche, Philippe Archambault, Piepenburg, Piepenburg, Piepenburg, Pirtle-Levy, Price, Rachold, Rachold, Reigstad, Renaud, Renaud, Renaud, Rho, Riser, Rowe, Rowe, Roy, Rysgaard, Rysgaard, Rysgaard, Sakshaug, Sampei, Sampei, Sauter, Sauter, Schewe, Schewe, Schmid, Schuur, Seiler, Serreze, Solan, Soltwedel, Soltwedel, Solveig Bourgeois, Stief, Stroeve, Suess, Sun, Sun, Søreide, Søreide, Tamelander, Tank, Thamdrup, Tremblay, Tremblay, Ursula Witte, Wakeham, Wassmann, Welch, Wexels Riser, Witte, Wollenburg, Wollenburg, Woodgate, Yang, Zabel   +166 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Climate Change and Water-Related Infectious Diseases

Atmosphere, 2018
Background: Water-related, including waterborne, diseases remain important sources of morbidity and mortality worldwide, but particularly in developing countries.
Gordon Nichols, Iain Lake, Clare Heaviside   +2 more
doaj   +1 more source

Continuous moulting by Antarctic krill drives major pulses of carbon export in the north Scotia Sea, Southern Ocean

Nature Communications, 2020
Antarctic krill are known to be important to the carbon cycle, but the exact contribution is not known. Here the authors show that krill moulting is a major vector of carbon export in the Southern Ocean, together with krill faecal pellets accounting for ...
C. Manno, S. Fielding, G. Stowasser, E. J. Murphy, S. E. Thorpe, G. A. Tarling   +5 more
doaj   +1 more source

Nature value of the environment in Poland and its protection [PDF]

, 2014
Published in: Natural environment of Poland and its protection in Łódź University Geographical Research, edited by E.
Majchrowska, Anna, Papińska, Elżbieta
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Automatic image segmentation method for cotton leaves with disease under natural environment

Journal of Integrative Agriculture, 2018
In order to improve the image segmentation performance of cotton leaves in natural environment, an automatic segmentation model of diseased leaf with active gradient and local information is proposed.
Jian-hua ZHANG, Fan-tao KONG, Jian-zhai WU, Shu-qing HAN, Zhi-fen ZHAI   +4 more
doaj   +1 more source

Learning Interpretable Spatial Operations in a Rich 3D Blocks World

, 2017
In this paper, we study the problem of mapping natural language instructions to complex spatial actions in a 3D blocks world. We first introduce a new dataset that pairs complex 3D spatial operations to rich natural language descriptions that require ...
Bisk, Yonatan, Choi, Yejin, Marcu, Daniel, Shih, Kevin J.   +3 more
core   +1 more source