Results 71 to 80 of about 5,709,277 (284)
Can virtual nature improve patient experiences and memories of dental treatment? A study protocol for a randomized controlled trial [PDF]
, 2014 Background Dental anxiety and anxiety-related avoidance of dental care create significant problems for patients and the dental profession. Distraction interventions are used in daily medical practice to help patients cope with unpleasant procedures ...
Andrade, J +10 more
core +4 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Poverty, environment and natural resource use: introduction to the special issue [PDF]
, 2008 A growing population and growing per capita consumption threaten the environment and the natural resource base. Where natural resources are at risk, the livelihoods of many are at risk as well.
Ierland, E.C., van, Weikard, H.P.
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Natural environment analysis [PDF]
Qualitative analyses (and quantitatively to the extend possible) of the influence of terrain features on wind loading of the space shuttle while on the launch pad, or during early liftoff, are presented.
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Bulletin of Geography. Socio-Economic Series, 2014 The aim of the study is an analysis of the environmental competitiveness of Lubelskie and Kujawsko-Pomorskie voivodships. There was performed an analysis of indices of the condition and protection of the environment, and also of the pressures placed on ...
Kasztelan Armand
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Neoliberalising technoscience and environment: EU policy for competitive, sustainable biofuels [PDF]
, 2012 This chapter discusses how EU biofuels policy: stimulates new markets for knowledge as well as resources; assumes that markets drive beneficent innovation; and thus deepens links between markets, technoscience and environment.
Birch, Kean +2 more
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source