Results 61 to 70 of about 572,242 (262)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Tolerance to occasional frosts during germination in Chilean Altiplano quinoa (Chenopodium quinoa Willd.) cultivars

Frontiers in Plant Science
Quinoa (Chenopodium quinoa Willd.) is increasingly cultivated in marginal environments; however, early-season frosts pose a major constraint to successful stand establishment.
Ignacio Delfino Yurin, José Delatorre-Herrera, Juan Pablo Rodríguez, José Pablo Delatorre-Castillo, Isabel Sepúlveda-Soto, Cristopher Low-Pfeng   +5 more
doaj   +1 more source

A Novel Fabrication Approach for Multifunctional Graphene-based Thin Film Nano-composite Membranes with Enhanced Desalination and Antibacterial Characteristics

Scientific Reports, 2017
A practical fabrication technique is presented to tackle the trade-off between the water flux and salt rejection of thin film composite (TFC) reverse osmosis (RO) membranes through controlled creation of a thinner active selective polyamide (PA) layer ...
Hanaa M. Hegab, Ahmed ElMekawy, Thomas G. Barclay, Andrew Michelmore, Linda Zou, Dusan Losic, Christopher P. Saint, Milena Ginic-Markovic   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Assessing the capacity of trees and shrubs species to accumulate of particulate matter (PM10, PM2.5 and PM0.2)

سلامت و محیط, 2019
Background and Objective: Today, the presence and increase of particulate matter is one of the serious factors that threaten human health. In the meantime, trees can accumulate airborne particles by their foliage.
M Hatami-Manesh, S Mortazavi, E Solgi, A Mohtadi   +3 more
doaj  

Planetary Health and the Future of Human Capacity: The Increasing Impact of Planetary Distress on the Human Brain

Challenges, 2018
All awareness, thoughts, emotions, perceptions, memories, actions—everything that encompasses our human capacity and reality—are mediated through the biological interface of our brains.
Chong Chen, Shin Nakagawa
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Floating Microplastics with Biofilm Changes Feeding Behavior of Climbing Perch Anabas testudineus

Microplastics
The climbing perch, Anabas testudineus, is one of the most widely distributed freshwater amphibious fishes in South and Southeast Asia, inhabiting both natural and artificial water bodies polluted by plastic waste.
Ekaterina V. Ganzha, Tran Duc Dien, Efim D. Pavlov   +2 more
doaj   +1 more source