Results 111 to 120 of about 9,282,571 (270)

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Prompts have evil twins [PDF]

We discover that many natural-language prompts can be replaced by corresponding prompts that are unintelligible to humans but that provably elicit similar behavior in language models.
Wakhare, Tanay, McCabe, Lucas H., Kim, Yejin, Huang, H. Howie, Melamed, Rimon, Boix-Adsera, Enric   +5 more
core  

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Inordinatio Boni

TheoLogica
If God is the origin of all being, but is not the origin of evil, it must follow that evil is not a being. That is, evil has no positive existence. As such, evil is always a parasitic absence of the good; its sting lies in the deprivation of some good ...
Sean Luke
doaj   +1 more source

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

Advanced Science, EarlyView.
A mitochondrial‐targeted FeCD‐SS31 nanoplatform integrates ROS‐responsive SS31 release with cascade antioxidant Fe3O4/CDs cores to suppress both de novo and existing ROS. By restoring mitochondrial complex integrity and blocking caspase‐1–GSDMD‐N pyroptosis, it reduces neutrophil infiltration and alleviates hepatic ischemia–reperfusion injury, while ...
Qianying Du, Lian Xu, Tingting Xia, Wenli Zhang, Sijin Chen, Xiyue Rong, Ying Luo, Yi Wang, Jia Liu, Yun Liu, Haitao Ran, Dajing Guo, Jie Xu   +12 more
wiley   +1 more source

The Problem of Evil: A Solution From Science

Zygon, 2001
In this essay, I attempt to solve the problem of the existence of evil in a world created by an omniscient, omnibenevolent, omnipotent God. I conclude that evil exists because God wanted to create moral creatures.
doaj   +2 more sources

Live Evil

Intro -- Live Evil: Of Magic and Men -- Table of Contents -- Introduction -- Literary Movements and the Emerging Question: 'Can Evil Exist Today?' -- Evil as Opposition to Self in American Literature and Contemporary Culture -- The Abyss of Freedom: The ...
Kottmayer, Sophia Vivienne.
core  

5. The problem of evil

, 2018
Evil represents the most serious challenge to belief in God. Philosophers of religion typically distinguish between two versions of the problem of evil: the logical and the evidential problem.
Tim Bayne
core   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Mediating the Morals of Disasters: Hurricane Katrina in Norwegian News Media

Nordic Journal of Science and Technology Studies, 2014
The Norwegian media responses to Hurricane Katrina were structured around three well-established sets of motifs in a globalized late modern disaster discourse: 1) The collapse of civil society, 2) Social vulnerability 2) Extreme weather and global ...
Kyrre Kverndokk
doaj