Results 61 to 70 of about 9,282,571 (270)

Privationist theodicy and the doctrine of transcendentals: Francisco Suarez on goodness and evil [PDF]

Вестник Православного Свято-Тихоновского гуманитарного университета: Серия I. Богословие, философия, 2018
The article attempts to discover the natural boundaries of the privationist theodicy (privatio boni) in the light of the criticism against it in recent Russian periodical literature, that evil cannot be considered as pure non-being, since it exits within
Kirill Karpov
doaj   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

A Comparison between Swinburne’s and Mutahari’s views on the Problem of Evil [PDF]

پژوهشنامه فلسفه دین, 2014
The problem of evil, as raised by Mutahari and Swinburne, is one of the most important and complicated problems concerning belief in God and teleology of the world.
Hamidreza Ekandari Damaneh, Ghasem Purhasan   +1 more
doaj   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Analysis and comparison of main evil characters in gothic novels Mary Shelley’s “Frankenstein” and Oscar Wilde’s “The Picture of Dorian Gray”. [PDF]

, 2011
The Picture of Dorian Gray by Oscar Wilde and Frankenstein by Mary Shelley are both products of Gothic Literature and though written in 70 years intervals, two novels embody main evil characters who are surprisingly similar .
Maraş, İzel
core   +1 more source

The ‘Problem of Evil’ in the context of the French enlightenment: Bayle, Leibniz, Voltaire, de Sade [PDF]

, 2012
The ‘problem of evil’ in its most general form concerns the question of the consistency of the mere existence of ‘evil’ in the created world with the characteristics attributed to its creator.
Lhost, Claudine
core  

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

The Problem of Evil in Nature: Evolutionary Bases of the Prevalence of Disvalue

Relations, 2015
This paper examines the problem of evil in nature, that is, the issue of the disvalue present in nature, and the question of whether or not it prevails over happiness. The paper claims that disvalue actually outweighs happiness in nature.
Oscar Horta
doaj   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source