Results 81 to 90 of about 9,282,571 (270)
Advanced Science, EarlyView.The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang +6 more
wiley +1 more source
Advanced Science, EarlyView.A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou +12 more
wiley +1 more source
Moral Evil and International Relations
, 2005 This essay seeks to situate and contextualize contemporary debates about evil in international relations by placing them in their historical, theological and philosophical contexts.
Jeffery, Renée, Rengger, Nicholas
core +3 more sources
GOD AND A WORLD OF NATURAL EVIL: THEOLOGY AND SCIENCE IN HARD CONVERSATION
Zygon: Journal of Religion and Science, 2022 C. Southgate
semanticscholar +1 more source
Advanced Science, EarlyView.An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan +7 more
wiley +1 more source
The poetics of evil : a study of the aesthetic theme in theodicy [PDF]
, 2009 This work proposes to look at the role of aesthetics within Christian theodicy. Though the recent theodicy literature has often displayed suspicion toward the inclusion of aesthetic criteria, I will argue that theological aesthetics can enrich the ...
Tallon, Philip
core +2 more sources
Advanced Science, EarlyView.In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang +10 more
wiley +1 more source
EVOLUTION AND THEODICY: HOW (NOT) TO DO SCIENCE AND THEOLOGY
Zygon, 2018 This article uses Christopher Southgate's work and engagement with other scholars on the topic of evolutionary theodicy as a case study in the dialogue of science and Christian theology.
doaj +2 more sources
STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis
Advanced Science, EarlyView.STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen +19 more
wiley +1 more source
The problem of morality in the Manichaean cosmological and soteriologic system
Anales del Seminario de Historia de la Filosofía, 2004 Manicheism is founded in two world originating ontological principles: Good or Light, presented by the sun and Evil or Darkness, personinified in the matter.
Marcos Roberto Nunes Costa
doaj