Results 81 to 90 of about 467,199 (313)

Courage [PDF]

open access: yes, 2012
In this chapter, DeYoung looks at the culturally and historically recognized virtue of courage. She specifically questions how we should think of all the pictures of courage and where we might look for Christlike examples of courage.
DeYoung, Rebecca
core  

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong   +8 more
wiley   +1 more source

The Limits of Theodicy: An Eastern Orthodox Perspective on Evil and Interreligious Theology [PDF]

open access: yes, 2016
This essay is written from the vantage point of a comparative theologian who is personally steeped in the Eastern Orthodox Christian tradition and who primarily specializes in Christian-Muslim comparative theology.
Monge, Rico G.
core   +3 more sources

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

open access: yesAdvanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu   +8 more
wiley   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

open access: yesAdvanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi   +15 more
wiley   +1 more source

The problem of morality in the Manichaean cosmological and soteriologic system

open access: yesAnales del Seminario de Historia de la Filosofía, 2004
Manicheism is founded in two world originating ontological principles: Good or Light, presented by the sun and Evil or Darkness, personinified in the matter.
Marcos Roberto Nunes Costa
doaj  

EVOLUTION AND THEODICY: HOW (NOT) TO DO SCIENCE AND THEOLOGY

open access: yesZygon, 2018
This article uses Christopher Southgate's work and engagement with other scholars on the topic of evolutionary theodicy as a case study in the dialogue of science and Christian theology.
doaj   +2 more sources

A Comparative Approach to the Problem of Evil from a Theological and Philosophical Perspective

open access: yesULUM, 2018
The problem of evil is the common problem of both philosophy and theology. Philosophers and kalām scholars have developed a theodicy/defense of divine justice that is in keeping with their understanding of religion, paradigms and methodologies. They have
Metin Özdemir
doaj   +1 more source

Cosmological Argument: A Pragmatic Defense [PDF]

open access: yes, 2010
We formulate a sort of "generic" cosmological argument, i.e., a cosmological argument that shares premises (e.g., "contingent, concretely existing entities have a cause") with numerous versions of the argument.
Megill, Jason L., Sandsmark, Evan
core   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon   +21 more
wiley   +1 more source

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