Results 31 to 40 of about 47,533 (149)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Impact of Natural Factors on Net Primary Productivity in Heilongjiang Province Under Different Land Use and Land Cover Changes

open access: yesAgronomy
Net primary productivity (NPP) is a vital indicator of carbon sequestration and ecosystem resilience. However, the dynamics of NPP across different land use types and especially the interactive function of natural drivers remain insufficiently quantified
Baohan Li   +5 more
doaj   +1 more source

Morocco’s Atlantic coast: Exploring and discovering sites at high risk of marine erosion [PDF]

open access: yesE3S Web of Conferences
Morocco's Atlantic coastline stretches from Tangier to Lagouira over a distance of around 3,000 km. It displays considerable geomorphological diversity depending on the structural domains, the nature and age of the terrain adjacent to the coastal profile,
Naji El Miloudiya   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The Influence of Regional Socioeconomic Features On the Distribution of Financial Resources For Higher Education [PDF]

open access: yesSocioEconomic Challenges
The article is devoted to solving the problem of “budgetary financial adequacy of higher education” in China through a fairer, uniform, and sufficient distribution of financial costs for higher education among the provinces of this country, considering ...
Yang Yu   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Analysis of criteria for UCG siting and operation [PDF]

open access: yesActa Montanistica Slovaca, 2009
Long-standing investigations into coal have enabled the identification of essential features of the course of the underground coal gasification (UCG) process as well the role and significance of some factors.
Barbara Białecka
doaj  

High-Throughput Viability Testing of Microbial Communities in a Probiotic Product Using Flow Cytometry

open access: yesApplied Microbiology, 2023
There is growing scientific and commercial interest in multi-species probiotic products due to their potential benefits in maintaining gut health. Determining the viability of probiotic microorganisms in these products is essential to ensure that they ...
Joanna V. Pereira   +5 more
doaj   +1 more source

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