Results 71 to 80 of about 62,872 (295)

Analysis of the Causes and Conditions for the Formation of a High Incidence of Acute Respiratory Infections in the Population of the Altai Krai (Part 2. Environmental factors, diagnosis of coxiellosis and tick­borne rickettsiosis)

Эпидемиология и вакцинопрофилактика
Relevance. Altai Krai (AK) is one of the least prosperous subjects of the Russian Federation in terms of the incidence of acute respiratory infections (ARI).
A. I. Blokh, N. A. Pen'evskaya, N. V. Rudakov, S. V. Shtrek, S. N. Shpynov, O. F. Egorova, Kh. A. Manokhina, D. A. Saveliev, S. Yu. Krasotkina   +8 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Epizootiological Monitoring of Natural Focal Infections in the South of the European Part of the Russian Federation in 2017

, 2019
Objective – analysis of epizootiological manifestations of natural focal infections in the territory of the south of the European part of the Russian Federation in 2017.Materials and methods.
L. I. Shaposhnikova, O. V. Maletskaya, Ya. V. Lisitskaya, E. A. Manin, T. V. Taran, A. N. Kulichenko, N. F. Vasilenko, N. G. Varfolomeeva, D. A. Prislegina, A. S. Volynkina, O. V. Semenko, E. V. Gerasimenko   +11 more
core   +1 more source

Epidemiological Situation on Rickettsioses in the Russian Federation in 2013–2024 and Short-Term Incidence Forecast for 2025

Проблемы особо опасных инфекций
The aim of the review was to conduct a comparative analysis of the epidemiological situation regarding rickettsioses in the constituent entities of the Russian Federation for the period of 2013–2024, and to provide a forecast of the incidence for 2025 ...
S. V. Shtrek, N. V. Rudakov, S. N. Shpynov, A. I. Blokh, D. V. Trankvilevsky, D. A. Savel’ev, N. A. Pen’evskaya, A. V. Sannikov, I. E. Irishkova, O. N. Skudareva   +9 more
doaj   +1 more source

MONITORING OF NATURAL FOCAL INFECTIONS ON THE SOUTHERN EUROPEAN PART OF RUSSIA IN 2016

ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT, 2018
The results of epizootological monitoring of the Southern European part of Russia (Southern and North- Caucasian Federal Districts), which has been tested for 18 nosological forms of natural focal infections are presented. There have been tested the laboratory studies of 45 615 samples of field material, the markers of pathogens of 15 nosological forms
N.F. Vasilenko, O.V. Maletskaya, E.A. Manin, D.A. Prislegina, L.I. Shaposhnikova, A.S. Volynkina, Ya.V. Lisitskaya, N.G. Varfolomeyeva, null A.N. Kulichenko   +8 more
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Epidemiological Situation on Natural Focal Infectious Diseases in the Territory of the North-Caucasian Federal District in 2015

, 2016
Objective of the study is to analyze epidemiological and epizootiological manifestations of natural-focal infections in the territory of the North-Caucasian Federal District (NCFD) in 2015. Materials and methods.
V. M. Dubyansky, L. I. Shaposhnikova, O. V. Maletskaya, Ya. V. Lisitskaya, E. A. Manin, T. V. Taran, A. N. Kulichenko, N. F. Vasilenko, D. A. Prislegina, A. S. Volynkina, E. S. Kotenev, G. M. Grizhebovsky   +11 more
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source