Results 31 to 40 of about 89,870 (258)

Tracing the Spatial Circulation of Yersinia pestis of Medieval Biovar in the Eastern Caspian Sea Region in the 20th Century Based on Genome-Wide SNP Analysis

Проблемы особо опасных инфекций, 2022
A comprehensive analysis of the accumulated epidemiological and epizootiological data in combination with results from phylogenetic analysis of Yersinia pestis strains creates the basis for establishing patterns of spatialtemporal distribution of the ...
G. A. Eroshenko, E. G. Oglodin, A. N. Balykova, Ya. M. Krasnov, E. A. Naryshkina, T. Z. Ayazbaev, N. V. Popov, V. V. Kutyrev   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The First Study of Borrelia burgdorferi Sensu Lato Persistence in Small Mammals Captured in the Ixodes persulcatus Distribution Area in Western Siberia

Pathogens
Borrelia burgdorferi sensu lato (s.l.) persistence in reservoir hosts is essential for the maintenance of the spirochaetes in the enzootic cycle. In this study, we investigated the persistence of Siberian B. burgdorferi s.l. strains in naturally infected
Vera Rar, Valeriy Yakimenko, Yana Igolkina, Yuliya Sabitova, Valeria Fedorets, Alfrid Karimov, Gavril Rubtsov, Tamara Epikhina, Nina Tikunova   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

CARRIER SPECIES OF TICK-BORNE INFECTIONS IN KEMEROVO REGION

Фундаментальная и клиническая медицина, 2017
Aim. Investigation of infection rate and species composition of ticks responsible for tick-borne infections in Kemerovo Region. Materials and Methods.
ANNA R. Efimova, SVETLANA A. Rudakova, OLGA M. Drozdova, NIKOLAY V. Rudakov, VALERIY V. Yakimenko   +4 more
doaj  

Prognostication of Epizootiologic Activity of Plague Natural Foci in the Russian Federation for 2009

Проблемы особо опасных инфекций, 2009
A short-term prognosis of plague epizootic activity in 11 natural foci in the Russian Federation for 2009 is substantiated by the authors. The present situation with the numbers of the main carriers and vectors of plague infection in diverse types of ...
N. V. Popov, V. E. Bezsmertny, V. P. Toporkov, S. M. Ivanova, V. P. Popov, A. I. Udovikov, L. D. Shilova, V. V. Kutyrev   +7 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Epizootic Activity of Natural Plague Foci in the Territory of the Russian Federation in 2011, and Prognosis for 2012

Проблемы особо опасных инфекций, 2012
Carried out is the assessment of epizootic activity of natural plague foci in the Russian Federation and in the Republic of Kazakhstan during the period of 2000-2010.
N. V. Popov, V. E. Bezsmertny, A. N. Matrosov, A. A. Kuznetsov, T. V. Knyzeva, V. P. Popov, D. B. Verzhutsky, L. S. Nemchenko, L. D. Shilova, V. M. Dubyansky, O. V. Maletskaya, V. P. Toporkov, A. V. Toporkov, A. K. Adamov, V. V. Kutyrev   +14 more
doaj   +1 more source