Results 41 to 50 of about 89,870 (258)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Prognostication of Epizootiologic Activity of Plague Natural Foci the Russian Federation for 2008

Проблемы особо опасных инфекций, 2008
A short-term prognosis of plague epizootic activity in 11 natural foci in the Russian Federation for 2008 is substantiated by the authors. The present situation with the numbers of the main carriers and vectors of plague infection in diverse types of ...
N. V. Popov, V. E. Bezsmertny, N. L. Novikov, A. I. Udovikov, A. A. Kouznetsov, V. N. Popov, L. D. Shilova, V. V. Kutyrev   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Genetic Diversity of Siberian Isolates of Borrelia burgdorferi Sensu Lato by the ospA Gene

Microorganisms
The genetic diversity of the ospA gene of the Borrelia burgdorferi sensu lato species complex encoding outer surface protein A has been widely investigated.
Yana Igolkina, Vera Rar, Valeriy Yakimenko, Alevtina Bardasheva, Valeria Fedorets, Alfrid Karimov, Gavril Rubtsov, Tamara Epikhina, Nina Tikunova   +8 more
doaj   +1 more source

Epidemiological Situation on Tularemia in the far Eastern Federal District (2000-2017)

Эпидемиология и вакцинопрофилактика, 2019
Relevance Tularemia - natural focal zoonotic infection occupies an important place in the structure of human infectious pathology. The incidence is associated with natural foci, where there are favorable conditions for the existence of the pathogen, its ...
T. N. Demidova, V. P Popov, T. V. Mikhailova, A. S. Cemichin, Y. S. Podobedova   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Epidemiological and Epizootic Situation on Plague in the Russian Federation and Forecast for Its Development for 2020–2025

Проблемы особо опасных инфекций, 2020
Objective of the investigation was to assess epidemiological and epizootiological conditions in natural plague foci of the Russian Federation, neighboring states and foreign countries in 2019.
N. V. Popov, G. A. Eroshenko, I. G. Karnaukhov, A. A. Kuznetsov, A. N. Matrosov, A. V. Ivanova, A. M. Porshakov, M. N. Lyapin, V. M. Korzun, D. B. Verzhutsky, T. Z. Ayazbaev, A. A. Lopatin, U. M. Ashibokov, S. V. Balakhonov, A. N. Kulichenko, V. V. Kutyrev   +15 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source