Results 41 to 50 of about 89,262 (295)

SNP-Profiles of Yersinia pestis Strains of the Medieval Biovar from the Caspian Sea Region Plague Foci

Проблемы особо опасных инфекций, 2023
The SNP-typing method based on the detection of stable genetic markers in the genome, i.e., single nucleotide polymorphisms, is successfully used for genotyping of pathogenic microorganisms and can be applied for SNP-profiling of Yersinia pestis strains ...
A. N. Balykova, L. M. Kukleva, P. A. Goryunova, K. S. Shevchenko, A. V. Kovrizhnikov, Ya. M. Krasnov, N. S. Chervyakova, G. A. Eroshenko, V. V. Kutyrev   +8 more
doaj   +1 more source

Combined Natural Foci of Bacterial, Rickettsial and Viral Infectious Diseases in the North-West Precaspian Region

, 2010
Presence of combined natural foci of plague, tularemia, Crimean-Congo hemorrhagic fever, West-Nile encephalitis, Astrakhan spotted fever in the North-West Precaspian region was substantiated.
E. V. Kouklev, A. I. Kovtunov, V. B. Sandzhiev, S. A. Scherbakova, K. B. Yashkulov, A. K. Adamov, A. V. Podsvirov, N. V. Piskunova, A. N. Matrosov, T. V. Knyazeva, V. V. Kabin, O. V. Maletskaya, M. P. Grigoryev, V. P. Toporkov, G. V. Sangadzhieva, A. A. Kuznetsov, N. V. Popov, V. P. Ossipov, A. I. Kologorov   +18 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The First Study of Borrelia burgdorferi Sensu Lato Persistence in Small Mammals Captured in the Ixodes persulcatus Distribution Area in Western Siberia

Pathogens
Borrelia burgdorferi sensu lato (s.l.) persistence in reservoir hosts is essential for the maintenance of the spirochaetes in the enzootic cycle. In this study, we investigated the persistence of Siberian B. burgdorferi s.l. strains in naturally infected
Vera Rar, Valeriy Yakimenko, Yana Igolkina, Yuliya Sabitova, Valeria Fedorets, Alfrid Karimov, Gavril Rubtsov, Tamara Epikhina, Nina Tikunova   +8 more
doaj   +1 more source

Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1

, 2014
This work is supported by the Scottish Universities Life Science Alliance (SULSA) and the Biotechnology and Biological Sciences Research Council (BBSRC) via a Ph.D.
Coleman, Stewart, Sleeman, Judith E., Coleman, Stewart M., Prescott, Alan R., Sleeman, Judith Elizabeth, Prescott, Alan R.; id_orcid   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

CARRIER SPECIES OF TICK-BORNE INFECTIONS IN KEMEROVO REGION

Фундаментальная и клиническая медицина, 2017
Aim. Investigation of infection rate and species composition of ticks responsible for tick-borne infections in Kemerovo Region. Materials and Methods.
ANNA R. Efimova, SVETLANA A. Rudakova, OLGA M. Drozdova, NIKOLAY V. Rudakov, VALERIY V. Yakimenko   +4 more
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source